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NOVEL CARRIER MOLECULE AND METHOD BOTH FOR DELIVERING RNA INTO CYTOPLASM USING NEAR-INFRARED LIGHT コモンズ

外国特許コード F130007322
整理番号 S2011-0272-C0
掲載日 2013年4月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2011JP077075
国際公開番号 WO 2012/127739
国際出願日 平成23年11月24日(2011.11.24)
国際公開日 平成24年9月27日(2012.9.27)
優先権データ
  • 特願2011-063953 (2011.3.23) JP
発明の名称 (英語) NOVEL CARRIER MOLECULE AND METHOD BOTH FOR DELIVERING RNA INTO CYTOPLASM USING NEAR-INFRARED LIGHT コモンズ
発明の概要(英語)

The purpose of the present invention is to provide a means for introducing RNA into a cell utilizing near-infrared light that has good biological tissue permeability (preferably having a wavelength of about 700-1000 nm) without causing the problem of cytotoxicity or heat generation. A carrier molecule according to the present invention is characterized by having a structure comprising: a carrier protein which comprises a cell-membrane-permeable peptide (CPP) and an RNA-binding protein (RBP)

and a photosensitizer (PST) which is connected to the N-terminal side or the C-terminal side of the carrier protein and can act upon the irradiation with light having a wavelength falling within a near infrared region. A (carrier molecule)/RNA complex composed of the carrier molecule and RNA bound to the RBP in the carrier molecule is formed, the complex is brought into contact with a cell to localize the complex in an endosome in the cell, and subsequently the cell is irradiated with near infrared light with which the PST in the (carrier molecule)/RNA complex can act. In this manner, the (carrier molecule)/RNA complex can be dispersed in a cytoplasm, whereby the function of the introduced RNA can be exerted.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY,
  • OHTSUKI, TAKASHI,
  • ISHIODORI, YUKA
  • 発明者(英語)
  • OHTSUKI, TAKASHI,
  • ISHIODORI, YUKA
国際特許分類(IPC)

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