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METHOD FOR INDUCING PROTEOLYSIS IN EUKARYOTIC CELL

外国特許コード F130007381
整理番号 S2012-0021-N0
掲載日 2013年6月5日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP079744
国際公開番号 WO 2013/073653
国際出願日 平成24年11月16日(2012.11.16)
国際公開日 平成25年5月23日(2013.5.23)
優先権データ
  • 特願2011-252147 (2011.11.18) JP
発明の名称 (英語) METHOD FOR INDUCING PROTEOLYSIS IN EUKARYOTIC CELL
発明の概要(英語)

Provided are: a novel protein-inducible eukaryotic cell which does not kill a host such as budding yeast and has a satisfactory decomposition ability

and a method for inducing proteolysis using the protein-inducible eukaryotic cell. A proteolysis-inducible non-plant eukaryotic cell, which has a plant-derived TIR1 family protein gene and a chimeric gene capable of expressing a desired protein labeled with a partial sequence of a plant-derived Aux/IAA family protein, and in which the degradation of the desired protein can be induced by an auxin, said non-plant eukaryotic cell being characterized in that the partial sequence is a sequence comprising a region containing at least two Lys residues on each of the N-terminal side and the C-terminal side of a domain II region of an Aux/IAA family protein or a sequence composed of a linked product of two or more of the aforementioned sequences.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS,
  • OSAKA UNIVERSITY
  • 発明者(英語)
  • KANEMAKI, MASATO,
  • NISHIMURA, KOHEI,
  • TAKISAWA, HARUHIKO,
  • MIMURA, SATORU,
  • KOBATA, YUI
国際特許分類(IPC)

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