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IMPDH INHIBITOR HAVING MICRORNA AS ACTIVE COMPONENT

外国特許コード F130007397
整理番号 S2012-0155-N0
掲載日 2013年6月12日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP079467
国際公開番号 WO 2013/077228
国際出願日 平成24年11月14日(2012.11.14)
国際公開日 平成25年5月30日(2013.5.30)
優先権データ
  • 特願2011-257158 (2011.11.25) JP
発明の名称 (英語) IMPDH INHIBITOR HAVING MICRORNA AS ACTIVE COMPONENT
発明の概要(英語)

Provided is a novel IMPDH inhibitor based on miRNA. This IMPDH inhibitor has, as an active component, oligonucleotides based more specifically on a miR-19a. The oligonucleotides based on miR-19a comprise a base sequence shown in any of 1) to 5) below: 1) the base sequence represented by sequence number 1 (UGUGCAAAUCUAUGCAAAACUGA)

2) the base sequence represented by sequence number 2 (AGUUUUGCAUAGUUGCACUACA)

a base sequence obtained by substitution, deletion, insertion, or addition of one to three nucleotides to a base sequence shown in sequences 1 or 2

base sequences complementary to the base sequences of oligonucleotides shown in any of 1) to 3) above

and base sequences which encode any of the oligonucleotides in 1) to 4) above. The aforementioned oligonucleotides suppress biosynthesis of IMPDH proteins by acting on the mRNA of the IMPDH gene, and can function as an IMPDH inhibitor.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • 発明者(英語)
  • OUCHIDA, MAMORU
国際特許分類(IPC)

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