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DRUG FOR PRODUCING RADIOLABELED POLYPEPTIDE REDUCING NON-SPECIFIC RENAL ACCUMULATION

外国特許コード F130007411
整理番号 S2012-0175-N0
掲載日 2013年6月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP081033
国際公開番号 WO 2013/081091
国際出願日 平成24年11月30日(2012.11.30)
国際公開日 平成25年6月6日(2013.6.6)
優先権データ
  • 特願2011-263647 (2011.12.1) JP
発明の名称 (英語) DRUG FOR PRODUCING RADIOLABELED POLYPEPTIDE REDUCING NON-SPECIFIC RENAL ACCUMULATION
発明の概要(英語)

Provided is a radiolabeled drug which contains a compound expressed in the following formula (I)

the compound to which polypeptide is bound which is capable of being bound to a target site, or a pharmacologically acceptable salt of the compound

and a complex which includes a complex structure which contains the compound to which the polypeptide is bound which is capable of being bound to the target site, or the pharmacologically acceptable salt thereof, and a radioisotope. (I) Herein, R1 is a hydrogen atom, a methyl group, or a carboxymethyl group

R2 is CH2-CH2-NH-CH2-COOH, CH2-CH2-N(CH2-COOH)2, CH2-CH2-NH2, CH2-CH2-NHR3, the carboxymethyl group, or CH2-CH2-NR3R4

R3 and R4 are alkyl groups which may be different

X, Y, and Z are amino acids which may be different

and F is a functional group which is capable of being bound to the polypeptide. Using the compound according to the present invention, the radiolabeled drug is provided which is prepared through a simple operation, has high accumulation toward the target site, and reduces non-specific renal accumulation.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
  • 発明者(英語)
  • ARANO, YASUSHI,
  • UEHARA, TOMOYA,
  • HANAOKA, HIROFUMI,
  • SUZUKI, CHIE
国際特許分類(IPC)

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