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CELL ADHESION INHIBITOR, CELL PROLIFERATION INHIBITOR, AND METHOD AND KIT FOR TESTING CANCER

外国特許コード F130007418
整理番号 S2011-0746-C0
掲載日 2013年6月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP062226
国際公開番号 WO 2012/157589
国際出願日 平成24年5月11日(2012.5.11)
国際公開日 平成24年11月22日(2012.11.22)
優先権データ
  • 特願2011-108685 (2011.5.13) JP
発明の名称 (英語) CELL ADHESION INHIBITOR, CELL PROLIFERATION INHIBITOR, AND METHOD AND KIT FOR TESTING CANCER
発明の概要(英語)

[Problem] To provide: a means for preventing/treating cancer by controlling the expression/function of a target cell that is different from those employed in conventional means, as a novel means to be employed in a molecular targeting therapy for cancer

a means for screening for a substance having a prophylactic/therapeutic activity on cancer, which utilizes the target molecule

and a simple and rapid means for testing cancer utilizing the detection of the target molecule. [Solution] According to one embodiment of the present invention, a cell proliferation inhibitor and a cell adhesion inhibitor for cancer cells are provided, each of which comprises an antibody against a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2 or a partial peptide of the protein. According to another embodiment of the present invention, a cell adhesion inhibitor for cancer cells is provided, which comprises an antisense polynucleotide comprising a nucleotide sequence complementary to or substantially complementary to a nucleotide sequence for a polynucleotide that encodes a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2 or a part of the nucleotide sequence. According to a further embodiment of the present invention, a cell adhesion inhibitor for cancer cells is provided, which comprises a substance capable of inhibiting the expression and/or activity of a protein that comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2. According to a still another embodiment of the present invention, a method for testing cancer is provided, which comprises a step of detecting a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2 or a partial peptide of the protein, or detecting a polynucleotide that encodes a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2. Further provided is a test kit for use in the method, which comprises an antibody against a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2 or a partial peptide of the protein, or comprises a primer or probe for detecting a polynucleotide that encodes a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF MIYAZAKI,
  • MORISHITA, KAZUHIRO,
  • SAITO, YUSUKE
  • 発明者(英語)
  • MORISHITA, KAZUHIRO,
  • SAITO, YUSUKE
国際特許分類(IPC)

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