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Therapeutic drug for adult T-cell leukemia

外国特許コード F130007505
掲載日 2013年7月10日
出願国 アメリカ合衆国
出願番号 200913120114
公報番号 20110172185
公報番号 8765719
出願日 平成21年8月20日(2009.8.20)
公報発行日 平成23年7月14日(2011.7.14)
公報発行日 平成26年7月1日(2014.7.1)
国際出願番号 JP2009064557
国際公開番号 WO2010032582
国際出願日 平成21年8月20日(2009.8.20)
国際公開日 平成22年3月25日(2010.3.25)
優先権データ
  • 特願2008-242867 (2008.9.22) JP
  • 特願2008-256620 (2008.10.1) JP
  • 特願2009-068750 (2009.3.19) JP
  • 2009JP064557 (2009.8.20) WO
発明の名称 (英語) Therapeutic drug for adult T-cell leukemia
発明の概要(英語) An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect.
The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each ―CR3R4―, ―SiR3R4― or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.
特許請求の範囲(英語) [claim1]
1. A method for treating adult T-cell leukemia comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by the formula I:
wherein
R1 is H, OH, an alkoxy group, a linear or branched, saturated or unsaturated aliphatic acyl group containing 1 to 10 carbon atoms, a benzoyl group, a naphthoyl group, a linear or branched, saturated or unsaturated aliphatic thioacyl group containing 1 to 10 carbon atoms, a thiobenzoyl group, or a thionaphthoyl group, and
R2 is a linear or branched, saturated or unsaturated aliphatic acyl group containing 1 to 10 carbon atoms, a benzoyl group, a naphthoyl group, a linear or branched, saturated or unsaturated aliphatic thioacyl group containing 1 to 10 carbon atoms, a thiobenzoyl group, a thionaphthoyl group, CONR7R8, or CSNR7R8, wherein R7 and R8 are each independently selected from H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group, or
R1 and R2 together form a ring as represented by -- OCH2CH2CO -- or -- OCH.dbd.CHCO -- ,
X1 and X2 are each independently selected from -- CR3R4 -- and -- SiR3R4 -- , and
R3 and R4 are each independently selected from an alkyl group containing 1 to 6 carbon atoms; wherein the compound represented by the formula I is a compound represented by the following formula:
[claim2]
2. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula III:
[claim3]
3. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula IV:
[claim4]
4. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula VI:
[claim5]
5. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula A:
[claim6]
6. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula B:
[claim7]
7. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula E:
[claim8]
8. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula F:
[claim9]
9. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula G:
[claim10]
10. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula M:
  • 発明者/出願人(英語)
  • BABA MASANORI
  • HASHIMOTO YUICHI
  • KAGOSHIMA UNIVERSITY
国際特許分類(IPC)
米国特許分類/主・副
  • 514/63
  • 514/455
  • 514/617
  • 514/649
  • 514/682
  • 514/700
  • 514/706
  • 549/389
  • 556/432
  • 564/180
  • 564/344
  • 568/20
  • 568/328
  • 568/440
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