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DESIGN METHOD FOR RNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF 新技術説明会

外国特許コード F130007569
掲載日 2013年7月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP077274
国際公開番号 WO 2013/058404
国際出願日 平成24年10月22日(2012.10.22)
国際公開日 平成25年4月25日(2013.4.25)
優先権データ
  • 特願2011-231346 (2011.10.21) JP
発明の名称 (英語) DESIGN METHOD FOR RNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF 新技術説明会
発明の概要(英語)

Provided is a method for designing a protein capable of selectively binding RNA bases or specifically binding an RNA base sequence. This protein includes 1 or more (preferably 2-14) PPR motifs comprising a polypeptide represented by formula (1) and having a length of 30-38 amino acids (in formula (1): Helix A is a moiety which is represented by formula (2), has a length of 12 amino acids, and is capable of forming an alpha-helix structure (in formula (2), A1-A12 each independently represent an amino acid)

X is a moiety which is either not present or which has a length of 1-9 amino acids

Helix B is a moiety that has a length of 11-13 amino acids, and is capable of forming an alpha-helix structure

L is a moiety which is represented by formula (3) and has a length of 2-7 amino acids (in formula (3), each amino acid is numbered from the C-terminus in the following manner "i"(-1), "ii"(-2), on condition that in some cases Liii to Lvii are not present)). The protein corresponding to the RNA bases or base sequence that will be bound is obtained by combining: A1, A4, and 3 Lii amino acids

or A4 and 2 Lii amino acids.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
  • 発明者(英語)
  • NAKAMURA, TAKAHIRO,
  • YAGI. YUSUKE,
  • KOBAYASHI, KEIKO
国際特許分類(IPC)
上記の特許・技術に関心のある方は、下記問合せ先にご相談下さい。

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