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Laser doppler blood flow measuring method and device

外国特許コード F130007571
掲載日 2013年7月19日
出願国 アメリカ合衆国
出願番号 80973808
公報番号 20100280398
公報番号 9031640
出願日 平成20年12月19日(2008.12.19)
公報発行日 平成22年11月4日(2010.11.4)
公報発行日 平成27年5月12日(2015.5.12)
国際出願番号 JP2008073245
国際公開番号 WO2009081883
国際出願日 平成20年12月19日(2008.12.19)
国際公開日 平成21年7月2日(2009.7.2)
優先権データ
  • 特願2007-330112 (2007.12.21) JP
  • 2008JP073245 (2008.12.19) WO
発明の名称 (英語) Laser doppler blood flow measuring method and device
発明の概要(英語) [Subject] To provide laser Doppler blood flow measuring method and device which achieve multi-dimensional measurement efficiently at a high degree of accuracy over a wide range with a simple optical system and device. [Solving Means] Laser light from a semiconductor laser 12 is split and formed into sheet lights Ls using a cylindrical lens 22, and the sheet lights Ls are crossed with each other at a predetermined position.
A lens system 30 configured to form an image of scattered lights into a linear shape at a linear irradiation site Lx where the sheet lights Ls cross with each other is provided.
An optical fiber array 32 having a plurality of optical fibers 34 is provided at an image-forming position of the lens system 30.
Avalanche photodiodes 42 configured to convert the scattered lights which are shifted in frequency by the Doppler effect caused by the blood flow into electric signals for the each optical fiber 34 are provided.
The blood flow velocity in a tissue of a biological body at the linear irradiation site Lx is calculated from the scattered lights transformed from the laser light by being shifted in frequency by the Doppler effect and is scanned for the each optical fiber 34, whereby the blood flow velocity in the blood vessel in a predetermined area in the biological body is calculated.
特許請求の範囲(英語) [claim1]
1. A laser Doppler blood flow measuring method comprising: splitting infrared laser light emitted from a laser light source into split laser lights, transforming the split laser lights into thin sheet lights, and crossing the sheet lights with each other at a linear irradiation site at a position in a biological body, wherein the sheet lights are scattered into scattered lights at the linear irradiation site, and wherein among the scattered lights, scattered lights which are scattered by blood cells in a blood flow in a blood vessel in the biological body are shifted in frequency due to the Doppler effect, and scattered lights which are scattered by stationary tissue are not shifted in frequency due to the Doppler effect;
receiving, by an optical system, the scattered lights from the linear irradiation site;
emitting the scattered lights from the optical system such that the scattered lights are in a linear shape and are emitted onto a plurality of light-receiving elements which are arranged in a linear shape;
performing photoelectric conversion of the scattered lights by a plurality of photoelectric conversion elements which correspond to the plurality of light-receiving elements to obtain electric signals corresponding to the scattered lights;
processing the electric signals obtained by the photoelectric conversion, to obtain frequencies of the scattered lights;
obtaining positional information about the blood vessel in the biological body from positions of ones of the plurality of light-receiving elements which receive the scattered lights which have been shifted in frequency by the Doppler effect; and
calculating a blood flow velocity in the blood vessel using Doppler frequency shifts of the scattered lights which were scattered by the blood cells in the blood flow;
wherein the method further comprises scanning the sheet lights to move the linear irradiation site in two directions orthogonal to a longitudinal direction in which the linear irradiation site extends and along a direction parallel to the longitudinal direction, and obtaining information about the blood flow in the blood vessel in three dimensions using the frequencies of the scattered lights at a plurality of positions to which the linear irradiation site is moved by the scanning; and
wherein the obtaining of the information about the blood flow in the blood vessel in three dimensions includes obtaining the positional information about the blood vessel and obtaining the blood flow velocity in the blood vessel at the plurality of positions to which the linear irradiation site is moved by the scanning.
[claim2]
2. The method according to claim 1, wherein the optical system is an image forming optical system which is positioned on a same side as a light-collecting optical system which applies the sheet lights to the linear irradiation site.
[claim3]
3. The method according to claim 1, wherein the optical system is an image forming optical system which is positioned on an opposite side of the tissue of the biological body from a light-collecting optical system which applies the sheet lights to the linear irradiation site.
[claim4]
4. The method according to claim 1, wherein the light-receiving elements and photoelectric conversion elements are provided by a solid state imaging device.
[claim5]
5. The laser Doppler blood flow measuring method according to claim 1, wherein a wavelength of the infrared laser light is 750 to 1500 nm.
[claim6]
6. The laser Doppler blood flow measuring method according to claim 2, wherein the plurality of light-receiving elements are positioned between the sheet lights.
[claim7]
7. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes an inner diameter of the blood vessel.
[claim8]
8. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes a mapping of the blood flow in the blood vessel in three dimensions.
[claim9]
9. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes a distribution of the blood flow velocity in three dimensions.
[claim10]
10. The laser Doppler blood flow measuring method according to claim 9, wherein the information about the blood flow in the blood vessel in three dimensions includes information on temporal variation of the distribution of the blood flow velocity in three dimensions.
[claim11]
11. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes an average blood flow velocity in a measurement range of the blood vessel.
[claim12]
12. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes a thickness of the blood vessel.
[claim13]
13. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes a blood flow rate in the blood vessel.
[claim14]
14. The laser Doppler blood flow measuring method according to claim 1, wherein the information about the blood flow in the blood vessel in three dimensions includes an arrangement of the blood vessel in the biological body in three dimensions.
[claim15]
15. The laser Doppler blood flow measuring method according to claim 1, further comprising displaying information about the blood vessel.
  • 発明者/出願人(英語)
  • HACHIGA TADASHI
  • ISHIDA HIROKI
  • AKIGUCHI SHUNSUKE
  • SHIRAKAWA HIROKI
  • ANDOH TSUGUNOBU
  • KURAISHI YASUSHI
  • INSTITUTE OF NATIONAL COLLEGES OF TECHNOLOGY, JAPAN
  • UNIVERSITY OF TOYAMA
国際特許分類(IPC)
米国特許分類/主・副
  • 600/479
  • 600/476
  • 600/504
  • 600/310
  • 356/342

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