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Inhibitor of HMGB protein-mediated immune response activation, and screening method

外国特許コード F130007603
整理番号 AF22-02WO
掲載日 2013年8月9日
出願国 中華人民共和国
出願番号 201180044442
公報番号 103096899
公報番号 103096899
出願日 平成23年9月14日(2011.9.14)
公報発行日 平成25年5月8日(2013.5.8)
公報発行日 平成27年1月28日(2015.1.28)
国際出願番号 JP2011071023
国際公開番号 WO2012036215
国際出願日 平成23年9月14日(2011.9.14)
国際公開日 平成24年3月22日(2012.3.22)
優先権データ
  • 2011JP071023 (2011.9.14) WO
  • 特願2010-209587 (2010.9.17) JP
  • 特願2011-138825 (2011.6.22) JP
発明の名称 (英語) Inhibitor of HMGB protein-mediated immune response activation, and screening method
発明の概要(英語) Provided is an inhibitor of HMGB protein-mediated immune response activation, comprising one or more compounds selected from the group consisting of phosphorothioate oligonucleotides and derivatives thereof.
Also provided is a method for screening an inhibitor or promoter of HMGB protein-mediated immune response activation, comprising: a mixing step of mixing an HMGB protein and a labeled nucleic acid in the presence and absence of a test substance; a assaying step of assaying the HMGB protein bound to the labeled nucleic acid; and a determination step of determining that the test substance is an inhibitor of HMGB protein-mediated immune response activation in the case that the quantity of the HMGB protein bound to the labeled nucleic acid in the presence of the test substance is less than the quantity of the HMGB protein bound to the labeled nucleic acid in the absence of the test substance, and determining that the test substance is a promoter of HMGB protein-mediated immune response activation in the case that the quantity of the HMGB protein bound to the labeled nucleic acid in the presence of the test substance is greater than the quantity of the HMGB protein bound to the labeled nucleic acid in the absence of the test substance.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • TANIGUCHI TADATSUGU
  • YANAI HIDEYUKI
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases AREA
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