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NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME

外国特許コード F130007612
整理番号 S2012-0300-N0
掲載日 2013年8月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP051733
国際公開番号 WO 2013/111897
国際出願日 平成25年1月28日(2013.1.28)
国際公開日 平成25年8月1日(2013.8.1)
優先権データ
  • 特願2012-015982 (2012.1.27) JP
発明の名称 (英語) NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME
発明の概要(英語)

The present invention provides a novel antitumor agent with a novel action mechanism. The novel antitumor agent comprises, as the active ingredient, a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein (RhoGAP). The RhoGAP, which depends on the cell cycle, plays an important role in the course of the acquisition of metastatic ability and/or invasive ability by cancer cells. By targeting the RhoGAP, the invasion and/or metastasis of cancer cells can be controlled. As the substance capable of inhibiting the cell cycle-dependent RhoGAP, an antisense oligonucleotide against an RhoGAP-encoding gene, an oligonucleotide inducing RNA interference, etc. can be cited. An oligonucleotide containing a synthetic nucleic acid such as BNA is preferred because of the high stability thereof. The present invention also provides a screening method for selecting an antitumor agent which is capable of suppressing the invasion and/or metastasis of cancer cells by a novel mechanism. This method for screening a novel antitumor agent is characterized in that a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein is selected thereby.

  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OSAKA UNIVERSITY
  • 発明者(英語)
  • ISHII, MASARU,
  • KAGAWA, YOSHINORI,
  • MORI, MASAKI,
  • ISHII, HIDESHI
国際特許分類(IPC)
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