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Microdroplet-producing apparatus コモンズ

外国特許コード F140007863
整理番号 09T275P/US
掲載日 2014年4月24日
出願国 アメリカ合衆国
出願番号 201113261564
公報番号 20130129581
公報番号 9200938
出願日 平成23年7月13日(2011.7.13)
公報発行日 平成25年5月23日(2013.5.23)
公報発行日 平成27年12月1日(2015.12.1)
国際出願番号 JP2011066004
国際公開番号 WO2012008497
国際出願日 平成23年7月13日(2011.7.13)
国際公開日 平成24年1月19日(2012.1.19)
優先権データ
  • 特願2010-158988 (2010.7.13) JP
  • 2011JP066004 (2011.7.13) WO
発明の名称 (英語) Microdroplet-producing apparatus コモンズ
発明の概要(英語) The present invention provides an apparatus for producing micro liquid drops through fine channels which can produce a large amount of micro liquid drops at low costs in an efficient manner.
The apparatus for producing micro liquid drops according to the present invention includes a fine channel substrate and a holder for holding the fine channel substrate.
The fine channel substrate has a micro liquid drop discharge outlet formed at the center thereof; a plurality of micro liquid drop producing sections which are connected to the micro liquid drop discharge outlet via the fine channels and disposed on the respective circumference of M circles or polygons arranged around the micro liquid drop discharge outlet; first-liquid drawing inlets which are disposed on the circumference of a circle or polygon arranged around the micro liquid drop discharge outlet; up-to-Nth-liquid drawing inlets (N is an integer equal to two or greater, M≰N-1) which are disposed on the respective circumference of circles or polygons arranged sequentially outward; and the fine channels through which the first- to Nth-liquids are supplied to the plurality of micro liquid drop producing sections.
The holder for holding the fine channel substrate has a multi-pipe structure which includes N annular channels for distributing an equal flow of the first- to Nth-liquids to the drawing inlet for each liquid in the fine channel substrate.
従来技術、競合技術の概要(英語) BACKGROUND ART
The present inventors have developed a method for producing an emulsion using the crossed form of microchannels as a means for producing microdroplets (emulsion) having an excellent size uniformity (monodispersity) (WO 02/068104).
This technology has made it possible to produce an emulsion of a uniform size, and to flexibly control the diameter and the formation speed of emulsion droplets by manipulating the flow rate in the channel.
The technology is being used in the production of a multi-phase emulsion (Kokai (Japanese Unexamined Patent Publication) No. 2004-237177), the preparation of globular solid microparticles (Kokai (Japanese Unexamined Patent Publication) No. 2004-059802 and Kokai (Japanese Unexamined Patent Publication) No. 2004-067953), the preparation of colored solid microparticles (Kokai (Japanese Unexamined Patent Publication) No. 2004-197083) and the like.
However, the above technology has problems that, with the crossed structure of only one microchannel, the upper limit of the flow rate for producing droplets is suppressed and the volume to be treated becomes smaller.
In order to resolve the problems, a number of examples on the development of apparatus in which a multitude of microchannels are arranged in parallel have been reported.
For example, there is a report on a microchannel board in which a total of 3 layers are stuck comprising (a) a layer of microchannels for distributing a dispersion phase, (b) a layer of microchannels for distributing a continuous phase liquid, and (c) a layer of Y-shaped microchannels for producing droplets (Kokai (Japanese Unexamined Patent Publication) No. 2004-243308).
On the other hand, the present inventors have developed an apparatus comprising: a microchannel board in which a multitude of microchannels in a crossed form for producing droplets are arranged; and a holder for retaining the microchannel board having a hierarchical structure to control the allocation of liquid to each microchannel (WO 2007/026564, Lab Chip, 2008, 8, 287-293).
However, in a microdroplet production apparatus as described above, the holder for retaining the microchannel board must be equipped with a plurality of liquid feeding paths corresponding to the plurality of inlet ports (liquid feeding ports) for feeding the dispersion phase and the continuous phase from outside the board to each of the channels of the microchannel board.
This structure has problems as described below.
First, as the number of channels to be arranged in parallel in the microchannel board becomes increased, the number of liquid feeding ports of the microchannel board must be increased.
Therefore, a multitude of liquid feeding paths must be provided at the corresponding positions in each hierarchical layer of the holder for retaining the microchannel board.
While it is desired, from the viewpoint of effectively using the board area, that the channels be arranged more densely on the microchannel board to increase the number of channels per unit area, this requires to minimize the size of the liquid feeding ports made on the microchannel board and the hole size of the corresponding liquid feeding paths of the holder for retaining the microchannel board.
Generally, a holder for retaining a microchannel board may be fabricated by machining, but the processing of a multitude of fine holes is technically difficult and leads to high cost.
Also, when fine holes are densely made on the holder for retaining a microchannel board, it becomes difficult to process the feeding ports for the dispersion phase or the continuous phase from the side of each hierarchical layer by passing through the gaps of vertical holes.
Also, a holder for retaining a microchannel board cannot be used for a microchannel board having the liquid feeding ports at different positions, and thus it disadvantageously lacks versatility.

PRIOR ART DOCUMENTS

Patent Documents
Patent Document 1: WO 02/068104
Patent Document 2: Kokai (Japanese Unexamined Patent Publication) No. 2004-237177
Patent Document 3: Kokai (Japanese Unexamined Patent Publication) No. 2004-059802
Patent Document 4: Kokai (Japanese Unexamined Patent Publication) No. 2004-067953
Patent Document 5: Kokai (Japanese Unexamined Patent Publication) No. 2004-197083
Patent Document 6: Kokai (Japanese Unexamined Patent Publication) No. 2004-243308
Patent Document 7: WO 2007/026564

Non-Patent Documents
Non-patent document 1: Lab Chip, 2008, 8, 287-293

特許請求の範囲(英語) [claim1]
1. An apparatus for producing microdroplets using microchannels, said apparatus comprising a microchannel board and a holder for retaining the microchannel board, wherein
the microchannel board has a microdroplet-outlet port formed at the center thereof, microdroplet-forming parts on a first to a Mth (M is an integer of 1 or more) annular or polygonal peripheries from inside to outside, said parts being connected through the microchannels to the microdroplet-outlet port and a plurality of said parts being disposed on each of M annular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for a first liquid disposed on annular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for liquids up to a Nth liquid (N is an integer of 2 or more, M <= N-1) sequentially disposed on annular or polygonal peripheries further outside of the above peripheries, and microchannels for feeding the first to the Nth liquids to the above plurality of microdroplet-forming parts, and
the holder for retaining the microchannel board has a coaxial multitube structure, with the microdroplet-outlet port as the central axis, having N annular or polygonal annular channels for allocating the even flow rate of the above first to the Nth liquids to the inlet port for each liquid of the microchannel board, wherein
N=2 (simultaneously M=1), the first liquid is a dispersion phase, and the second liquid is a continuous phase, and
the holder for retaining the microchannel structure has a third component which is disposed under the microchannel board and which is equipped with an inlet port for the continuous phase, a second component which is equipped with an inlet port for the dispersion phase and which forms annular or polygonal annular channels for feeding the continuous phase to the microchannel board in combination with the above third component, and a first component which forms a annular path for feeding the dispersion phase to the microchannel board in combination with the above second component and which is equipped, at the center thereof, with a cylinder having an outlet port for microdroplets from the microchannel board, wherein the first and second components are placed beneath the third component, and the first component is placed beneath the second component.
[claim2]
2. The apparatus for producing microdroplets according to claim 1, wherein the plurality of microdroplet-forming parts are where the dispersion phase liquid alternately joins with the continuous phase liquid from both sides.
[claim3]
3. An apparatus for producing microdroplets using microchannels, said apparatus comprising a microchannel board and a holder for retaining the microchannel board, wherein
the microchannel board has a microdroplet-outlet port formed at the center thereof, microdroplet-forming parts on a first to a Mth (M is an integer of 1 or more) annular or polygonal peripheries from inside to outside, said parts being connected through the microchannels to the microdroplet-outlet port and a plurality of said parts being disposed on each of M annular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for a first liquid disposed on annular or polygonal peripheries with the microdroplet-outlet port at the center, inlet ports for liquids up to a Nth liquid (N is an integer of 2 or more, M <= N-1) sequentially disposed on annular or polygonal peripheries further outside of the above peripheries, and microchannels for feeding the first to the Nth liquids to the above plurality of microdroplet-forming parts, and
the holder for retaining the microchannel board has a coaxial multitube structure, with the microdroplet-outlet port as the central axis, having N annular or polygonal annular channels for allocating the even flow rate of the above first to the Nth liquids to the inlet port for each liquid of the microchannel board, wherein
N=2 (simultaneously M=1), the first liquid is a continuous phase, and the second liquid is a dispersion phase, and
the holder for retaining the microchannel structure has a third component which is disposed under the microchannel board and which is equipped with an inlet port for the dispersion phase, a second component which is equipped with an inlet port for the continuous phase and which forms annular or polygonal annular channels for feeding the continuous phase to the microchannel board in combination with the above third component, and a first component which is equipped with an outlet port for the formed droplets from the holder and which forms a annular or polygonal annular channel for feeding the continuous phase to the microchannel board in combination with the above second component and which is equipped, at the center thereof, with a cylinder having an outlet port for microdroplets from the microchannel board, wherein the first and second components are placed beneath the third component, and the first component is placed beneath the second component.
[claim4]
4. The apparatus for producing microdroplets according to claim 3, wherein the plurality of microdroplet-forming parts are where the continuous phase joins with the above dispersion phase from both sides.
  • 発明者/出願人(英語)
  • NISISAKO TAKASI
  • TOKYO INSTITUTE OF TECHNOLOGY
国際特許分類(IPC)
米国特許分類/主・副
  • 2016/01/01

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