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METHOD FOR DETECTING PRIMARY ALDOSTERONISM, AND MONOCLONAL ANTIBODY

外国特許コード F140007915
整理番号 3978
掲載日 2014年8月13日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP076787
国際公開番号 WO 2014054675
国際出願日 平成25年10月2日(2013.10.2)
国際公開日 平成26年4月10日(2014.4.10)
優先権データ
  • 特願2012-222030 (2012.10.4) JP
発明の名称 (英語) METHOD FOR DETECTING PRIMARY ALDOSTERONISM, AND MONOCLONAL ANTIBODY
発明の概要(英語) The present invention provides a method for detecting aldosterone-producing adenoma (APA) and/or idiopathic hyperaldosteronism (IHA), which comprises the following steps (1) and (2): (1) a step of evaluating the activity of 3βHSD (3β-hydroxy-Δ5-steroid dehydrogenase), which is an enzyme essential for the production of aldosterone (A) and cortisol (F), in an adrenal gland sample (wherein 3βHSD mentioned above can act on both a pathway (A) for producing the substance (A), which is a pathway going through pregnenolone (P5) to progesterone (P4), and a pathway (F) for producing the substance (F), which is a pathway going through 17-hydroxypregnenolone (17OH-P5) to 17-hydroxyprogesterone (17OH-P4), and the 3βHSD activity is evaluated by calculating the pathway (A)/pathway (F) ratio (an AFR, which is produced by dividing the pathway (A) by the pathway (F)), which is a ratio representing the relative frequency of the pathway (A) compared with the pathway (F)); and (2) a step of detecting APA and/or IHA on the basis of the pathway (A)/pathway (F) ratio (AFR) calculated in step (1).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • TOHOKU UNIVERSITY
  • 発明者(英語)
  • OKAMURA HITOSHI
  • DOI MASAO
  • SATOH FUMITOSHI
  • SASANO HIRONOBU
  • MORIMOTO RYO
  • ITO SADAYOSHI
  • NAKAMURA YASUHIRO
  • TAKASE KEI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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