TOP > 外国特許検索 > METHOD FOR EVALUATING BOTH INDUCTION OF DRUG-METABOLIZING ENZYME AND CYTOTOXICITY, AND VECTOR AND CELL FOR USE IN SAID METHOD

METHOD FOR EVALUATING BOTH INDUCTION OF DRUG-METABOLIZING ENZYME AND CYTOTOXICITY, AND VECTOR AND CELL FOR USE IN SAID METHOD コモンズ

外国特許コード F140008030
整理番号 S2013-0049-C0
掲載日 2014年11月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP079058
国際公開番号 WO 2014061829
国際出願日 平成25年10月21日(2013.10.21)
国際公開日 平成26年4月24日(2014.4.24)
優先権データ
  • 特願2012-232018 (2012.10.19) JP
発明の名称 (英語) METHOD FOR EVALUATING BOTH INDUCTION OF DRUG-METABOLIZING ENZYME AND CYTOTOXICITY, AND VECTOR AND CELL FOR USE IN SAID METHOD コモンズ
発明の概要(英語) The purpose of the present invention is to evaluate the induction of a drug-metabolizing enzyme by a substance of interest more accurately compared with conventional methods in a simple manner using a vector in which a reporter gene is linked downstream of a region for suppressing the expression of a drug-metabolizing enzyme gene and a cell into which the vector is introduced. The present invention provides a vector for producing a cell that can be used for the evaluation of both the induction of a drug-metabolizing enzyme by a substance of interest and the cytotoxicity of the substance of interest, said vector comprising a region for suppressing the expression of a fetus-specific gene, a first reporter gene, a region for suppressing the expression of a drug-metabolizing enzyme gene and a second reporter gene, wherein the first reporter gene is located downstream of the region for suppressing the expression of the fetus-specific gene and the second reporter gene is located downstream of the region for suppressing the expression of the drug-metabolizing enzyme gene. The present invention also provides: a cell which carries the vector; and a method for evaluating both the induction of a drug-metabolizing enzyme by a substance of interest and the cytotoxicity of the substance of interest using the cell.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOTTORI UNIVERSITY
  • 発明者(英語)
  • TADA MASAKO
  • OSHIMURA MITSUO
  • KAWAMURA FUMIHIKO
  • TSUJI SAORI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
ライセンスをご希望の方、特許の内容に興味を持たれた方は、下記「問合せ先」まで直接お問い合わせください。

PAGE TOP

close
close
close
close
close
close