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AUTOMATED ESTIMATION METHOD OF INTRACELLULAR INTERMOLECULAR NETWORK BASED ON COMPREHENSIVE MULTI-LAYERED DATA

外国特許コード F140008047
整理番号 S2013-0197-C0
掲載日 2014年12月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP080103
国際公開番号 WO 2014080767
国際出願日 平成25年11月7日(2013.11.7)
国際公開日 平成26年5月30日(2014.5.30)
優先権データ
  • 特願2012-256440 (2012.11.22) JP
発明の名称 (英語) AUTOMATED ESTIMATION METHOD OF INTRACELLULAR INTERMOLECULAR NETWORK BASED ON COMPREHENSIVE MULTI-LAYERED DATA
発明の概要(英語) [Problem] To provide a technique for identifying, in a data driven manner, regulatory pathways over multiple layers on the basis of comprehensive data of metabolomes, phosphoproteomes and transcriptomes. [Solution] The intermolecular network estimation according to the present invention comprises: inputting metabolomic data as first input data; identifying a metabolite that shows a significant concentration change in the metabolomic data; assuming that a change in enzymatic activity causing the concentration change is induced by modification such as phosphorylation; and thus tracing back a causal relationship. Then, the estimation results of a metabolism controlling network, which mediates signaling from a stimulus, via a responsible modified enzyme and a boundary enzyme, to the metabolite, are output.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TOKYO
  • 発明者(英語)
  • YUGI KATSUYUKI
  • KUBOTA HIROYUKI
  • KURODA SHINYA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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