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METHOD AND KIT FOR DISTINGUISHING BETWEEN PROSTATE CARCINOMA AND BENIGN PROSTATIC HYPERPLASIA 新技術説明会

外国特許コード F150008105
掲載日 2015年2月9日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP077495
国際公開番号 WO 2014057983
国際出願日 平成25年10月9日(2013.10.9)
国際公開日 平成26年4月17日(2014.4.17)
優先権データ
  • 特願2012-226489 (2012.10.12) JP
発明の名称 (英語) METHOD AND KIT FOR DISTINGUISHING BETWEEN PROSTATE CARCINOMA AND BENIGN PROSTATIC HYPERPLASIA 新技術説明会
発明の概要(英語) The present invention addresses the problem of providing a method for distinguishing between prostate carcinoma and benign prostatic hyperplasia with high sensitivity and good reproducibility using an analyte sample in a small amount. The method for distinguishing between prostate carcinoma and benign prostatic hyperplasia according to the present invention, which is a solution for the problem, is as follows: an analyte sample containing a prostate-specific antigen (PSA) is brought into contact with a carrier having an anti-free PSA antibody immobilized thereon, thereby causing the binding of a free PSA to the anti-free PSA antibody immobilized on the carrier; the carrier in which the free PSA has been bound to the immobilized anti-free PSA antibody is brought into contact with a monoclonal antibody capable of specifically recognizing a sugar chain in which a terminal sialic acid residue is bound to galactose via an α(2,3) bond, thereby causing the binding of the monoclonal antibody capable of specifically recognizing the sugar chain in which the terminal sialic acid residue has been bound to galactose via an α(2,3) bond to the free PSA that has been bound to the anti-free PSA antibody immobilized on the carrier; the amount of the free PSA that has an N-type sugar chain in which the terminal sialic acid residue has been bound to galactose via an α(2,3) bond is measured; and subsequently the amount measured in the proceeding step is compared with a preset cut-off value for prostate carcinoma and benign prostatic hyperplasia. When the measured amount is larger than the cut-off value, it is determined that prostate carcinoma is developed or the probability of prostate carcinoma is high. When the measured amount is smaller than the cut-off value, it is determined that benign prostatic hyperplasia is developed or the probability of benign prostatic hyperplasia is high.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HIROSAKI UNIVERSITY
  • SHIZUOKA PREFECTURAL UNIVERSITY
  • 発明者(英語)
  • OHYAMA CHIKARA
  • YONEYAMA TOHRU
  • TOBISAWA YUKI
  • HATAKEYAMA SHINGO
  • SUZUKI TAKASHI
  • JWA ILPAL
  • YAMAGUCHI MAHO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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