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METHOD OF MANUFACTURING DIFFERENTIATED PLURIPOTENT STEM CELL

外国特許コード F150008107
掲載日 2015年2月9日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP079311
国際公開番号 WO 2014069479
国際出願日 平成25年10月29日(2013.10.29)
国際公開日 平成26年5月8日(2014.5.8)
優先権データ
  • 特願2012-237734 (2012.10.29) JP
発明の名称 (英語) METHOD OF MANUFACTURING DIFFERENTIATED PLURIPOTENT STEM CELL
発明の概要(英語) The present invention allows a TET1 protein to be more stably expressed in human differentiated pluripotent stem cells than in the past by, inter alia , substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, it is possible to quickly eliminate the expression of, inter alia , NANOG, which is an inhibitor of differentiation induction, and promote the expression of factors related to differentiation induction by introducing a variant TET1 protein to a differentiated pluripotent stem cell. The present invention provides a method for manufacturing differentiated pluripotent stem cells with increased differentiation performance, and a substance that is useful to said method.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAITAMA MEDICAL UNIVERSITY
  • 発明者(英語)
  • KATO HIDEMASA
  • MORIYAMA YOSUKE
  • HIRAKI KEIKO
  • OKUDA AKIHIKO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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