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KNOCK-IN MOUSE コモンズ

外国特許コード F150008196
掲載日 2015年3月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP053555
国際公開番号 WO 2014126225
国際出願日 平成26年2月14日(2014.2.14)
国際公開日 平成26年8月21日(2014.8.21)
優先権データ
  • 特願2013-026838 (2013.2.14) JP
発明の名称 (英語) KNOCK-IN MOUSE コモンズ
発明の概要(英語) The present invention addresses the problem of providing a knock-in mouse that develops Osaka-mutation-mediated Alzheimer's disease through gene expression in normal physiological ranges. The problem is solved by a knock-in mouse as described below. A knock-in mouse into which a mutant amyloid precursor protein (mutant APP) gene described in (a) or (b), below, has been introduced, said mouse being homozygous for the mutant APP gene. (a) A mutant APP gene that codes a mutant murine amyloid-β protein and comprises the amino acid sequence represented by SEQ ID NO: 1. (b) A mutant APP gene that codes a polypeptide which induces the onset of Alzheimer's disease when expressed in mice, said gene comprising the amino acid sequence represented by SEQ ID NO: 1, in which one or more amino acids other than the 5th glutamine residue from the N terminal, the 10th phenylalanine residue from the N terminal and the 13th arginine residue from the N terminal has/have been substituted, deleted, inserted or added.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OSAKA CITY UNIVERSITY
  • 発明者(英語)
  • MORI HIROSHI
  • TOYAMA TAKAMI
  • UMEDA TOMOHIRO
  • MORITA TAKASHI
  • YOSHIDA KAYO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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