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METHOD FOR ASSAYING MICRORNA, CANCER THERAPEUTIC AGENT, AND MEDICINAL COMPOSITION CONTAINING SAME FOR CANCER THERAPY

外国特許コード F150008207
掲載日 2015年3月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP053594
国際公開番号 WO 2014126233
国際出願日 平成26年2月17日(2014.2.17)
国際公開日 平成26年8月21日(2014.8.21)
優先権データ
  • 特願2013-027399 (2013.2.15) JP
発明の名称 (英語) METHOD FOR ASSAYING MICRORNA, CANCER THERAPEUTIC AGENT, AND MEDICINAL COMPOSITION CONTAINING SAME FOR CANCER THERAPY
発明の概要(英語) The present invention addresses the problem of finding a microRNA that strongly relates to the stabilization of NRF2 in a tumor and providing a means of utilizing the same in diagnosing and treating cancer. As the results of a screening of 470 kinds of microRNAs in a microRNA library with the use of HeLa cells, 8 kinds of microRNAs, each showing a large decrease in the activity compared with a control, and 8 kinds of microRNAs, each showing a large increase in the activity, were specified. It was discovered that, by using the microRNAs thus specified, the activation of NRF2 in a living body, in particular a tumor cell, can be detected and thus the malignancy, etc. of a tumor can be distinguished. Also, it was discovered that a nucleic acid containing a microRNA sequence relating to a decrease in the ARE activity as described above is usable as a cancer therapeutic agent.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO MEDICAL AND DENTAL UNIVERSITY
  • 発明者(英語)
  • INAZAWA JOHJI
  • INOUE JUN
  • YAMAMOTO SHINSUKE
  • KAWANO TATSUYUKI
  • KOZAKI KEN-ICHI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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