TOP > 外国特許検索 > METHOD FOR PRODUCING [18F]F- OR FLUORESCENT DYE-LABELED PEGYLATED BIOACTIVE SUBSTANCE, AND ANALYSIS OF IN VIVO KINETICS THEREOF

METHOD FOR PRODUCING [18F]F- OR FLUORESCENT DYE-LABELED PEGYLATED BIOACTIVE SUBSTANCE, AND ANALYSIS OF IN VIVO KINETICS THEREOF

外国特許コード F150008229
掲載日 2015年3月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP059034
国際公開番号 WO 2014157584
国際出願日 平成26年3月27日(2014.3.27)
国際公開日 平成26年10月2日(2014.10.2)
優先権データ
  • 特願2013-070277 (2013.3.28) JP
発明の名称 (英語) METHOD FOR PRODUCING [18F]F- OR FLUORESCENT DYE-LABELED PEGYLATED BIOACTIVE SUBSTANCE, AND ANALYSIS OF IN VIVO KINETICS THEREOF
発明の概要(英語) Provided is a novel technical means whereby temporal and spatial in vivo kinetics of a drug can be noninvasively and highly sensitively quantified in real time. An [18F]F-labeled or fluorescent dye-labeled pegylated bioactive substance represented by formula (I-a) or (I-b). In these formulae: Ra1 represents a divalent C1 to C6 hydrocarbon group; Rb1 to Rb10 represent a hydrogen atom, etc.; Rc1 represents a hydrogen atom, etc.; X represents a divalent C1 to C12 hydrocarbon group or -Rd1(OCH2CH2)mRd2- [wherein Rd1 represents a divalent C1 to C12 hydrocarbon group, etc., Rd2 represents a divalent C1 to C6 hydrocarbon group, etc., and m represents an integer being within the range of 1-40 kDa calculated in terms of molecular weight]; Y represents a monovalent group containing a bioactive substance; Z represents a monovalent group containing a fluorescent dye; and n represents an integer being within the range of 1-40 kDa calculated in terms of molecular weight.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF SHIZUOKA
  • 発明者(英語)
  • AKAI SHUJI
  • OKU NAOTO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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