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METHOD FOR INDUCING DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS INTO INTESTINAL EPITHELIAL CELLS

外国特許コード F150008296
整理番号 S2013-0597-C0
掲載日 2015年4月10日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP054379
国際公開番号 WO 2014132933
国際出願日 平成26年2月24日(2014.2.24)
国際公開日 平成26年9月4日(2014.9.4)
優先権データ
  • 特願2013-036434 (2013.2.26) JP
発明の名称 (英語) METHOD FOR INDUCING DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS INTO INTESTINAL EPITHELIAL CELLS
発明の概要(英語) The purpose of the present invention is to provide a novel method for efficiently inducing the differentiation of induced pluripotent stem cells into intestinal epithelial cells, and a use thereof. The differentiation of induced pluripotent stem cells into intestinal epithelial cells is induced by: a step in which induced pluripotent stem cells are differentiated into endoderm-like cells; a step in which the endoderm-like cells obtained at the aforementioned step are differentiated into intestinal stem cell-like cells; and a step in which the intestinal stem cell-like cells obtained at the aforementioned step are differentiated into intestinal epithelial cell-like cells, said step including culturing in the presence of EGF and at least one compound selected from the group consisting of MEK1 inhibitors, DNA methylation inhibitors, and TFGβ receptor inhibitors.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGOYA CITY UNIVERSITY
  • 発明者(英語)
  • IWAO TAKAHIRO
  • MATSUNAGA TAMIHIDE
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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