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NOVEL METHOD FOR LABELLING CANCERIZATION-CAUSING CELL IN STEM CELLS, AND THERAPY METHOD

外国特許コード F150008535
整理番号 (S2014-0307-N0)
掲載日 2015年11月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP000138
国際公開番号 WO 2015107888
国際出願日 平成27年1月14日(2015.1.14)
国際公開日 平成27年7月23日(2015.7.23)
優先権データ
  • 特願2014-004262 (2014.1.14) JP
発明の名称 (英語) NOVEL METHOD FOR LABELLING CANCERIZATION-CAUSING CELL IN STEM CELLS, AND THERAPY METHOD
発明の概要(英語) [Problem] The present invention addresses the problem of providing a method for searching for a best promoter for reliably targeting a cancerization-causing cell in human ES/iPS cells. The present invention also addresses the problem of discovering a gene which can kill or remove a cancerization-causing cell contained in human ES/iPS cells with high efficiency. The present invention further addresses the problem of providing a method for removing an undifferentiated cell, which remains after the differentiation of human ES/iPS cells into desired cells, with high efficiency and comprehensively. [Solution] A viral vector comprising a nucleotide sequence and a recombination cassette, wherein the nucleotide sequence contains a target gene and a killing gene that are linked to each other through a sequence that enables the simultaneous expression of the two genes by one promoter, and the recombination cassette contains a promoter region, and wherein the promoter region is so linked as to enable the expression of the labeling gene and the killing gene, said viral vector particularly containing a promoter specific to an undifferentiated cell as the promoter region; and others.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • KOSAI KEN-ICHIRO
  • MITSUI KAORU
  • IDE KANAKO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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