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METHOD FOR ENHANCING IMMUNE CELL FUNCTION AND METHOD FOR ASSESSING IMMUNE CELL MULTIFUNCTIONALITY

外国特許コード F160008765
整理番号 (S2014-1375-N0)
掲載日 2016年6月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP073011
国際公開番号 WO 2016027764
国際出願日 平成27年8月17日(2015.8.17)
国際公開日 平成28年2月25日(2016.2.25)
優先権データ
  • 特願2014-166593 (2014.8.19) JP
  • 特願2015-085556 (2015.4.20) JP
発明の名称 (英語) METHOD FOR ENHANCING IMMUNE CELL FUNCTION AND METHOD FOR ASSESSING IMMUNE CELL MULTIFUNCTIONALITY
発明の概要(英語) Provided are: a method for enhancing immune cell function by activating ex vivo various immune cells; and immune cells with enhanced function. Further provided is a method for assessing cell multifunctionality related to immunity. The multifunctionality of immune cells can be enhanced using a biguanide-based antidiabetic medication selected from any one of metformin, phenformin and buformin to increase CD8+ T cells, which have a high capacity for producing IL-2, TNFα, and IFNγ. Cell multifunctionality related to immunity can be assessed by comparing the multifunctionality of immune cells treated with a biguanide-based antidiabetic medication selected from any one of metformin, phenformin and buformin, and control immune cells not treated with the biguanide-based antidiabetic medication. If the immune cells treated with a biguanide-based antidiabetic medication selected from any one of metformin, phenformin and buformin have significantly improved multifunctionality compared to the control cells, said immune cells can be assessed as having improved sensitivity to said drug.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • 発明者(英語)
  • UDONO HEIICHIRO
  • EIKAWA SHINGO
  • TOYOOKA SHIN-ICHI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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