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ANTI-INFLUENZA VIRUS AGENT, AND SCREENING METHOD FOR ANTI-INFLUENZA VIRUS AGENT 新技術説明会

外国特許コード F160008787
整理番号 (E096P07)
掲載日 2016年8月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP076674
国際公開番号 WO 2016047592
国際出願日 平成27年9月18日(2015.9.18)
国際公開日 平成28年3月31日(2016.3.31)
優先権データ
  • 特願2014-192752 (2014.9.22) JP
発明の名称 (英語) ANTI-INFLUENZA VIRUS AGENT, AND SCREENING METHOD FOR ANTI-INFLUENZA VIRUS AGENT 新技術説明会
発明の概要(英語) The present invention provides an anti-influenza virus agent that targets biomolecules of host cells including human cells, and a method for screening for candidate molecules of the anti-influenza virus agent. The present invention is an anti-influenza virus agent which inhibits the function and expression of a gene that codes for a protein having inhibitory action against the uptake, to an influenza virus particle, of influenza virus vRNA or NP protein in a host cell, wherein the gene is at least one kind selected from the group consisting of JAK1 genes.
特許請求の範囲(英語) [claim1]
1.  Action to suppress the expression of genes encoding proteins involved in uptake of influenza virus-like particle of vRNA or NP protein of influenza virus in a host cell, or has an action to inhibit the function of the protein,  The gene, JAK1 gene, CHERP gene, DDX21 gene, DNAJC11 gene, EEF1A2 gene, HNRNPK gene, ITM2B gene, MRCL3 gene, MYH10 gene, NDUFS8 gene, PSMD13 gene, RPL26 gene, SDF2L1 gene, SDF4 gene, SFRS2B gene, SNRPC gene, SQSTM1 gene, TAF15 gene, TOMM40 gene, TRM2B gene, USP9X gene, and wherein the BASP1 gene, THOC2 gene, PPP6C gene, is TESC gene, and one or more selected from the group consisting of PCDHB12 gene, anti-influenza virus agent.
[2]
[claim2]
2.  It said gene is JAK1 gene or USP9X gene, anti-influenza virus agent according to claim 1.
[3]
[claim3]
3.  Ruxolitinib, Tofacitinib, Tofacitinib (CP-690550) Citrate, Tyrphostin B42 (AG-490), Baricitinib (LY3009104, INCB028050), AT9283, Momelotinib, CEP33779, NVP-BSK805, ZM39923, Filgotinib, JANEX-1, NVP-BSK805, SB1317 , and at least one selected from the group consisting of WP1130, anti-influenza virus agent according to claim 1.
[4]
[claim4]
4.  Action to suppress the expression of genes encoding proteins involved in replication or transcription of influenza virus in a host cell, or has an action to inhibit the function of the protein,  The gene, CCDC56 gene, CLTC genes, CYC1 gene, NIBP gene, ZC3H15 gene, C14orf173 gene, ANP32B gene, BAG3 gene, BRD8 gene, CCDC135 gene, DDX55 gene, DPM3 gene, EEF2 gene, IGF2BP2 gene, KRT14 gene, and characterized in that at least one member selected from the group consisting of S100A4 gene, anti-influenza virus agent.
[5]
[claim5]
5.  It acts to suppress the expression of genes encoding proteins involved in the formation of influenza virus-like particles in the host cell, or has an action to inhibit the function of the protein,  The gene, GBF1 gene, ASCC3L1 gene, BRD8 gene, C19orf43 gene, DDX55 gene, DKFZp564K142 gene, DPM3 gene, EEF2 gene, FAM73B gene, FLJ20303 gene, NCLN gene, from the group consisting of C14orf173 gene, LRPPRC gene, and RCN1 gene characterized in that one or more selected, anti-influenza virus agent.
[6]
[claim6]
6.  The gene is GBF1 gene, anti-influenza virus agent according to claim 5.
[7]
[claim7]
7.  A Golgicide A, anti-influenza virus agent according to claim 5.
[8]
[claim8]
8.  A method of screening candidate compounds for anti-influenza virus agents,  JAK1 gene, CHERP gene, DDX21 gene, DNAJC11 gene, EEF1A2 gene, HNRNPK gene, ITM2B gene, MRCL3 gene, MYH10 gene, NDUFS8 gene, PSMD13 gene, RPL26 gene, SDF2L1 gene, SDF4 gene, SFRS2B gene, SNRPC gene, SQSTM1 gene , TAF15 gene, TOMM40 gene, TRM2B gene, USP9X gene, BASP1 gene, THOC2 gene, PPP6C gene, TESC gene, PCDHB12 gene, CCDC56 gene, CLTC genes, CYC1 gene, NIBP gene, ZC3H15 gene, C14orf173 gene, ANP32B gene, BAG3 gene, BRD8 gene, CCDC135 gene, DDX55 gene, DPM3 gene, EEF2 gene, IGF2BP2 gene, KRT14 gene, S100A4 gene, GBF1 gene, ASCC3L1 gene, C19orf43 gene, DKFZp564K142 gene, FAM73B gene, FLJ20303 gene, NCLN gene, LRPPRC gene, and a characterized in that the expression or the gene of one or more genes selected from the group consisting of RCN1 genes compounds with inhibitory or ability to inhibit the function of a protein encoded and screened as candidate compounds for antiviral agents and, the screening method of the anti-influenza virus agent.
[9]
[claim9]
9.  The cell, introducing a compound of interest to assess whether the candidate compound of anti-influenza virus agents,  A step of measuring the expression level of said gene in a cell by introducing said compound,  A step expression level of said gene, for selecting if said compound is significantly reduced than the previous cell into which they are introduced, the compound as a candidate compound for an anti-influenza virus agents, The a method for screening anti-influenza virus agent according to claim 8.
[10]
[claim10]
10.  Protein that the gene encodes is an enzyme,  A step of the gene for the enzyme activity of the protein encoded, determined in the presence of a compound of interest to assess whether the candidate compound of anti-influenza virus agents,  Enzymatic activity of said protein in the presence of said compound, when lower than the absence of the compound, a step of selecting the compound as a candidate compound for an anti-influenza virus agents, The a method for screening anti-influenza virus agent according to claim 8.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KAWAOKA YOSHIHIRO
  • WATANABE TOKIKO
  • KAWAKAMI EIRYO
  • WATANABE SHINJI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
参考情報 (研究プロジェクト等) ERATO KAWAOKA Infection-induced Host Responses AREA
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