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CELL FOR PRODUCING INFLUENZA VIRUS, AND METHOD FOR PRODUCING INFLUENZA VIRUS 新技術説明会

外国特許コード F160008788
整理番号 (E096P08)
掲載日 2016年8月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP076681
国際公開番号 WO 2016047595
国際出願日 平成27年9月18日(2015.9.18)
国際公開日 平成28年3月31日(2016.3.31)
優先権データ
  • 特願2014-192753 (2014.9.22) JP
発明の名称 (英語) CELL FOR PRODUCING INFLUENZA VIRUS, AND METHOD FOR PRODUCING INFLUENZA VIRUS 新技術説明会
発明の概要(英語) Provided are a cell that can be cultured in vitro , said cell being highly capable of proliferating an influenza virus and appropriately usable for the production of the influenza virus for manufacturing a vaccine, and a method for producing the influenza virus using the aforesaid cell. The cell for producing an influenza virus according to the present invention is characterized in that the expression of at least one gene encoding a protein that participates in an effect of inhibiting the production of the influenza virus in cells is inhibited, said gene(s) being selected from a group consisting of ACTG1 gene, etc. The method for producing an influenza virus according to the present invention is characterized by comprising infecting the aforesaid cell for producing an influenza virus with the influenza virus and then culturing the cell.
特許請求の範囲(英語) [claim1]
1.  Expression of some genes in the chromosome is suppressed, a culturable cells in vitro,  The gene, ACTG1 gene, ACTN1 gene, ATCAY gene, CCT6A gene, COPS7B gene, DAP3 gene, ERLIN2 gene, GNAI2 gene, GTF3C5 gene, HNRPAB gene, KHSRP gene, KRT18 gene, MTCH1 gene, PPP2R1A gene, PRPS1 gene, RAB18 gene, RAB3A gene, RAP1B gene, RPS19 gene, RPS7 gene, S100A10 gene, SFRS7 gene, SLC2A12 gene, characterized in that it is a one or more of the genes selected from the group consisting of TMED2 gene, and USP10 gene, influenza virus production for the cell.
[2]
[claim2]
2.  The gene has been deleted or destroyed, influenza virus production for the cell according to claim 1.
[3]
[claim3]
3.  The gene, ACTG1 gene, ACTN1 gene, DAP3 gene, GNAI2 gene, GTF3C5 gene, KRT18 gene, MTCH1 gene, PRPS1 gene, RPS19 gene, S100A10 gene, SFRS7 gene, SLC2A12 gene, USP10 gene, PPP2R1A gene, and from TMED2 gene it is one or more selected from the group consisting of influenza virus production for cell according to claim 1 or 2.
[4]
[claim4]
4.  It is a cell derived from a mammalian influenza virus production for cell according to any one of claims 1-3.
[5]
[claim5]
5.  It is a cell derived from a human influenza virus production for cell according to claim 4.
[6]
[claim6]
6.  It is a cell derived from kidney, influenza virus production for cell according to claim 4.
[7]
[claim7]
7.  Used in the manufacture of influenza virus vaccines, influenza virus production for cell according to any one of claims 1-6.
[8]
[claim8]
8.  Influenza virus production for cell according to any one of claims 1 to 7, after infection with influenza virus, characterized by culturing, method of production of influenza virus.
[9]
[claim9]
9.  The influenza virus is an influenza virus for the production of influenza virus vaccines, methods of producing influenza virus of claim 8.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KAWAOKA YOSHIHIRO
  • WATANABE TOKIKO
  • KAWAKAMI EIRYO
  • WATANABE SHINJI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
参考情報 (研究プロジェクト等) ERATO KAWAOKA Infection-induced Host Responses AREA
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