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IN VIVO STEALTH NANOPARTICLE

外国特許コード F160008798
整理番号 (S2015-0216-N0)
掲載日 2016年8月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP006041
国際公開番号 WO 2016088384
国際出願日 平成27年12月4日(2015.12.4)
国際公開日 平成28年6月9日(2016.6.9)
優先権データ
  • 特願2014-247252 (2014.12.5) JP
発明の名称 (英語) IN VIVO STEALTH NANOPARTICLE
発明の概要(英語) Provided is a molecular imprint polymer that is capable of acquiring stealth properties through a new mechanism. The molecular imprint polymer according to the present invention, which has a plasma protein recognition site carrying a plasma protein molecularly imprinted thereon and contains a constituent derived from a biocompatible monomer, is an in vivo stealth nanoparticle to be used in intravascular delivery. As the plasma protein, albumin is preferred. When carrying a drug thereon, the in vivo stealth nanoparticle according to the present invention is usable as a drug for drug delivery system.
特許請求の範囲(英語) [claim1]
1.  A molecularly imprinted polymer comprising the components of plasma protein is derived from and biocompatible monomers having a plasma protein recognition sites that are molecularly imprinted, used for intravascular transport, in vivo stealth nanoparticles.
[2]
[claim2]
2.  The plasma protein is albumin, in vivo stealth nanoparticles of claim 1.
[3]
[claim3]
3.  Wherein the biocompatible monomer is a zwitterionic compound, in vivo stealth nanoparticles according to claim 1 or 2.
[4]
[claim4]
4.  The average particle diameter is 10nm or more 100nm or less, in vivo stealth nanoparticles of any one of claims 1 to 3.
[5]
[claim5]
5.  Further comprising a signal group, in vivo stealth nanoparticle of any one of claims 1 to 4.
[6]
[claim6]
6.  Drug component is supported, in vivo stealth nanoparticle of any one of claims 1 to 5.
[7]
[claim7]
7.  The pharmaceutical ingredient, the polymerizable functional group on the drug contained in the molecularly imprinted polymer as a constituent component derived from a drug monomers covalently bonded, in vivo stealth nanoparticle of claim 6.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KOBE UNIVERSITY
  • 発明者(英語)
  • TAKEUCHI TOSHIFUMI
  • KITAYAMA YUKIYA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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