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PEPTIDE-BOUND LIPOSOME, CYTOTOXIC T LYMPHOCYTE ACTIVATOR, AND ANTITUMOR VACCINE

外国特許コード F160008807
整理番号 (S2014-1594-N0)
掲載日 2016年8月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP076214
国際公開番号 WO 2016047509
国際出願日 平成27年9月16日(2015.9.16)
国際公開日 平成28年3月31日(2016.3.31)
優先権データ
  • 特願2014-196454 (2014.9.26) JP
発明の名称 (英語) PEPTIDE-BOUND LIPOSOME, CYTOTOXIC T LYMPHOCYTE ACTIVATOR, AND ANTITUMOR VACCINE
発明の概要(英語) A peptide-bound liposome wherein a peptide comprising the amino acid sequence represented by SEQ ID NO:14 is bound to the surface of a liposome.
特許請求の範囲(英語) [claim1]
1.  SEQ ID NO: Peptide consisting of the amino acid sequence of 14, a peptide-bound liposome, wherein a binding to the surface of the liposome.
[2]
[claim2]
2.  Liposomes, unsaturated bonds one having an acyl group with a carbon number of 14-24, and a phospholipid with either a hydrocarbon group having 14 to 24 carbon atoms having one unsaturated bond, liposome stabilizers peptide bond liposome according to claim 1, including a door.
[3]
[claim3]
3.  Phospholipid, peptide-bound liposome according to claim 2 is a phospholipid having an acyl group of 14 to 24 carbon atoms having one unsaturated bond.
[4]
[claim4]
4.  Acyl group, the peptide-bound liposome according to any one of claims 2 3 oleyl group.
[5]
[claim5]
5.  Phospholipids, diacyl phosphatidyl serine, diacyl phosphatidyl glycerol, diacyl phosphatidic acids, diacyl phosphatidylcholine, diacylphosphatidylethanolamine, succinimidyl - diacylphosphatidylethanolamine, and maleimide - claims 2 at least is one selected from diacyl phosphatidyl ethanolamine peptide-bound liposome according to any one of the four.
[6]
[claim6]
6.  Stabilizers liposomes, peptide-bound liposome according to any preceding claim 2 is cholesterol.
[7]
[claim7]
7.  Peptides, claims bonded to a phospholipid having any of a hydrocarbon group having 14 to 24 carbon atoms having one acyl group having a carbon number of 14-24, and unsaturated bond having one unsaturated bond peptide bond liposome according to any one of from 2 to 6.
[8]
[claim8]
8.  Cytotoxic T lymphocyte activation agent characterized by containing a peptide-bound liposome according to any one of claims 1 7.
[9]
[claim9]
9.  Furthermore, cytotoxic T lymphocyte activation agent according to claim 8 which contains an adjuvant.
[10]
[claim10]
10.  Anti-tumor vaccine comprising the peptide-bound liposome according to any one of claims 1 to 7.
[11]
[claim11]
11.  Furthermore, the anti-tumor vaccine according to claim 10 containing an adjuvant.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAITAMA MEDICAL UNIVERSITY
  • 発明者(英語)
  • HORIUCHI YUTAKA
  • AKATSUKA TOSHITAKA
  • UCHIDA TETSUYA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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