TOP > 外国特許検索 > METHOD FOR USING SYT7, MFSD4, AND ETNK2 EXPRESSION LEVELS TO DETECT METASTASIS OF GASTRIC CANCER TO LIVER, DETECTION KIT, METHOD FOR SCREENING MOLECULAR TARGETED THERAPEUTIC AGENT, AND PHARMACEUTICAL COMPOSITION

METHOD FOR USING SYT7, MFSD4, AND ETNK2 EXPRESSION LEVELS TO DETECT METASTASIS OF GASTRIC CANCER TO LIVER, DETECTION KIT, METHOD FOR SCREENING MOLECULAR TARGETED THERAPEUTIC AGENT, AND PHARMACEUTICAL COMPOSITION コモンズ

外国特許コード F160008842
整理番号 NU-657
掲載日 2016年9月1日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP063956
国際公開番号 WO 2016181979
国際出願日 平成28年5月11日(2016.5.11)
国際公開日 平成28年11月17日(2016.11.17)
優先権データ
  • 特願2015-097939 (2015.5.13) JP
発明の名称 (英語) METHOD FOR USING SYT7, MFSD4, AND ETNK2 EXPRESSION LEVELS TO DETECT METASTASIS OF GASTRIC CANCER TO LIVER, DETECTION KIT, METHOD FOR SCREENING MOLECULAR TARGETED THERAPEUTIC AGENT, AND PHARMACEUTICAL COMPOSITION コモンズ
発明の概要(英語) Provided are a detection method for predicting the metastasis of gastric cancer to the liver, a detection kit, and a method for screening a medicine which selectively acts on liver metastasis. By targeting SYT7, MFSD4, and ETNK2, the expression of which specifically changes during metastasis of gastric cancer to the liver, postoperative liver metastasis can be predicted or a molecular targeted therapeutic agent can be screened.
特許請求の範囲(英語) [claim1]
1. Being inspection method in order to estimate the liver transfer after the stomach excision technique of the stomach cancer,
The patient serum which was picked from the object, and/or calculating at least the revelation quantity of the one or more of SYT7, MFSD4 and ETNK2 in stomach cancer organizing in stomach excision technique,
At least in the revelation quantity of the one or more of SYT7, MFSD4 and ETNK2 in the sample specified value and when it can recognize significant difference, the inspection method of featuring that it decides that risk of liver transfer is high.
[claim2]
2. Being inspection method of statement in claim 1,
The revelation quantity of SYT7, MFSD4 and ETNK2, mRNA of SYT7, MFSD4 and ETNK2 and/or the inspection method of featuring that the protein revelation quantity is measured.
[claim3]
3. Being inspection method of claim 2 statement,
Measuring method of the mRNA revelation quantity of SYT7, MFSD4 and ETNK2 quantitative PCR, or the inspection method of featuring that it is something by the next generation sequencer.
[claim4]
4. Being inspection method of claim 1 statement,
As for the revelation quantity of MFSD4 the inspection method of featuring that it seeks by analyzing the DNA methylation state of the MFSD4 gene promoter territory.
[claim5]
5. Being the inspection kit in order it diagnoses or to estimate liver transfer after the stomach excision technique of the stomach cancer, or,
The primer for quantitative PCR in order to measure the revelation quantity of SYT7, MFSD4, or ETNK2, the anti- SYT7 antibody, the anti- MFSD4 antibody, or the anti- ETNK2 antibody, or either of the methylation detection reagent of the MFSD4 gene promoter territory the inspection kit which features that one or more is included.
[claim6]
6. Being the method the screening of doing the molecular target remedy in order to remedy the liver transfer after the stomach excising of the stomach cancer,
Control of the revelation quantity of SYT7 and ETNK2 and increase of the revelation quantity of MFSD4, or at least either of methylation of the MFSD4 gene promoter territory one as an index the molecular target remedy screening method of featuring that the screening it does the substance.
[claim7]
7. At least either SYT7 or ETNK2 the medicine composition in order to control the liver transfer after the stomach excision technique which includes one siRNA.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGOYA UNIVERSITY
  • 発明者(英語)
  • KANDA MITSURO
国際特許分類(IPC)
指定国 (WO2016181979)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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