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LACTATE DEHYDROGENASE INHIBITOR AND ANTIEPILEPTIC DRUG CONTAINING SAME

外国特許コード F160008857
整理番号 (S2015-0530-N0)
掲載日 2016年9月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP053764
国際公開番号 WO 2016129583
国際出願日 平成28年2月9日(2016.2.9)
国際公開日 平成28年8月18日(2016.8.18)
優先権データ
  • 特願2015-023572 (2015.2.9) JP
発明の名称 (英語) LACTATE DEHYDROGENASE INHIBITOR AND ANTIEPILEPTIC DRUG CONTAINING SAME
発明の概要(英語) The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.
特許請求の範囲(英語) [claim1]
1. The inhibiter of the lactic acid dehydrogenase which contains the chemical compound which is displayed with formula (iii).
In formula (iii),
R (a), displaying the alkoxy group which is possible to be substituted with the hydrogen atom, the halogen atom or the halogen atom,
Displaying the basis which forms the annular structure where R (b), you display the alkoxy group or nitro group which is possible to be substituted with the hydrogen atom, the halogen atom and the halogen atom, or R (c), R (d) or R (g) with becomes united and is possible to have possessed the substituent,
Displaying the basis which forms the annular structure where R (c), you display the hydrogen atom or the carboxyl group, or R (b), R (e) R (f) or R (g) with becomes united and is possible to have possessed the substituent,
Displaying the basis which forms the annular structure where R (d), the hydrogen atom or - X (11) - R (11) you display, or R (b) or R (g) with becomes united and is possible to have possessed the substituent,
X (11) alkylene basis, - NH-CO-, - CH [2] - NR (12) - [CO]-MATAHA-S-WO displaying,
R (11), the aryl basis and the carboxyl group which are possible to have possessed the substituent, displaying the alkyl group or the hydroxy alkyl group which is possible to be substituted with the halogen atom,
R (12), displaying hydroxy alkyl group,
R (e), R (f) and R (g),
(i) Does everything display the hydrogen atom?
(ii) R (e) and R (f) becoming simultaneous, =O and =NR (21) or =CR (21) R (22) to display, R (g), - X (31) - R (31), - O-X (32) - R (32), - N (- X (33) - R (33))(- X (34) - R (34))Or - CR (35) R (36) R (37) displaying,
Displaying the basis which forms the annular structure where R (21) you display the hydroxy basis, or R (c) or R (g) with becomes united and is possible to have possessed the substituent,
R (22), displaying the amino carbonyl group the hydrogen atom which is connected to the nitro group, or the nitrogen atom may be substituted with the alkyl group,
X (31), single bond and [arukeniren] basis, - CH [2] - O-CH [2] - CO-NH-, - CH [2] - O-CH [2] - [CO]-MATAHA-CO-WO displaying,
R (31), the aryl basis which is possible to have possessed the substituent, the hetero aryl basis which is possible to have possessed the substituent, the complex cyclic amino group which is possible to have possessed [shikuroarukiru] and the substituent which are possible to have possessed the substituent, the hydroxy basis, displaying alkoxy group or the hydroxy alkyl group which is possible to be substituted with the halogen atom,
However, when is X (31) single bond, R (31) is the complex cyclic amino group which is possible to have possessed the substituent, we connect particular single bond with the atom other than the nitrogen atom of the particular complex cyclic amino group,
X (32), single bond or - CH [2] - [CO]-NH-WO displaying,
R (32), the aryl basis which is possible to have possessed the substituent, the hetero aryl basis which is possible to have possessed the substituent, displaying the alkyl group which is possible to be substituted with the [shikuroarukiru] or halogen atom which is possible to have possessed the substituent,
X (33) and X (34) becoming independent respectively, single bond and the alkylene basis, - CH [2] - [CO]-NH-MATAHA-SO [2] - displaying,
R (33) and R (34) becoming independent respectively, the hydrogen atom, the aryl basis which is possible to have possessed the substituent, the hetero aryl basis which is possible to have possessed the substituent, [shikuroarukiru] and the hydroxyl alkyl group which are possible to have possessed the substituent, the carboxyl group, you display the alkyl group or [arukiniru] basis which is possible to be substituted with the halogen atom, or R (b), R (c), R (d) or R (e) R (f) with become united and you display the basis which forms the annular structure which is possible to have possessed the substituent or, R (33) and R (34)X where those are single bond (33) and X (34) through, with the nitrogen atom which has been connected becoming united, displaying the complex cyclic amino group which is possible to have possessed the substituent,
Displaying the basis which forms the annular structure where R (35), R (36) and R (37) becoming independent respectively, the hydrogen atom or - X (31) - R (31) you display, or, R (b), R (c), R (d) or R (e) R (f) with becomes united and is possible to have possessed the substituent,
R (h), the hydrogen atom or the halogen atom is displayed.
However, R (b) with R (c) the annular structure which becomes united, R (b) with R (d) the annular structure which becomes united, R (b) with R (g) the annular structure which becomes united, R (c) with R (e) R (f) the annular structure which becomes united, R (c) with R (g) the annular structure which becomes united, R (d) with R (g) the annular structure which becomes united, R (e) R (f) with R (g) one bodyAs for the annular structure which becomes, also many only one, is formed in formula (iii).
[claim2]
2. The chemical compound which is displayed with aforementioned formula (iii), R (c), R (d), R (e), R (f), R (g) is the chemical compound where everything is the hydrogen atom, in claim 1 the inhibiter of the lactic acid dehydrogenase of statement.
[claim3]
3. The chemical compound which is displayed with aforementioned formula (iii), is [isosahuroru] which is displayed with below-mentioned formula (ii), in claim 2 the inhibiter of the lactic acid dehydrogenase of statement.
[claim4]
4. The chemical compound which is displayed with aforementioned formula (iii), R (b) with R (c) the aforementioned annular structure which becomes united, R (b) with R (d) the aforementioned annular structure which becomes united, R (b) with R (g) the aforementioned annular structure which becomes united, R (c) with R (e) R (f) the aforementioned annular structure which becomes united, R (c) with R (g) the aforementioned annular structure which becomes united, R (d) with R (g) aforementioned annular structure, and R which become united (e)R (f) with R (g) it is the chemical compound where none of them of the aforementioned annular structure which becomes united is formed, in claim 1 the inhibiter of the lactic acid dehydrogenase of statement.
[claim5]
5. The chemical compound which is displayed with formula (iii), R (b) with R (c) the aforementioned annular structure which becomes united, R (b) with R (d) the aforementioned annular structure which becomes united, R (b) with R (g) the aforementioned annular structure which becomes united, R (c) with R (e) R (f) the aforementioned annular structure which becomes united, R (c) with R (g) the aforementioned annular structure which becomes united, R (d) with R (g) aforementioned annular structure, and R which become united (e)R (f) with R (g) either of the aforementioned annular structure which becomes united it is the chemical compound where one is formed, in claim 1 the inhibiter of the lactic acid dehydrogenase of statement.
[claim6]
6. Either of the claim 1-5 the anti- epilepsy medicine which designates the inhibiter of the lactic acid dehydrogenase of statement as the active ingredient in one section.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OKAYAMA UNIVERSITY
  • 発明者(英語)
  • INOUE TSUYOSHI
  • SADA NAGISA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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