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PRODUCTION METHOD FOR OPTICALLY ACTIVE COMPOUND, AND TRIAZOLIUM SALT USED AS CATALYST IN SAME コモンズ

外国特許コード F160008893
整理番号 NU-663
掲載日 2016年10月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP069888
国際公開番号 WO 2017006929
国際出願日 平成28年7月5日(2016.7.5)
国際公開日 平成29年1月12日(2017.1.12)
優先権データ
  • 特願2015-135120 (2015.7.6) JP
発明の名称 (英語) PRODUCTION METHOD FOR OPTICALLY ACTIVE COMPOUND, AND TRIAZOLIUM SALT USED AS CATALYST IN SAME コモンズ
発明の概要(英語) The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometalate with a compound represented by formula (3), in which R1-R3 are as described, under the presence of a triazolium salt represented by formula (2), in which R5 and R8-R10 are the same or different and represent an aryl group which may be substituted, R6 represents a primary alkyl group which may be substituted, R7 represents a fatty alkyl group which may be substituted, or a cycloalkyl group which may be substituted, and X1 represents a halogen atom or a monovalent anion.
特許請求の範囲(英語) [claim1]
1. General system (1):
[In formula, R (1) and R (2) differs, the alkyl group which is possible to be substituted, [shikuroarukiru] which is possible to be substituted, the [arukeniru] basis which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (3) shows the organic basis. ]
So being production method of the optical active chemical compound which is displayed,
General system (2):
[In formula, R (5) and R (8), -R (10) equality or differing, the alkyl group which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (6) shows the primary alkyl group which is possible to be substituted.
R (7) the aliphatic alkyl group which is possible to be substituted, or [shikuroarukiru] which is possible to be substituted is shown.
X (1) shows the halogen atom or the anion of 1 value. ]
So under existing of the [toriazoriumu] salt which is displayed,
General system (3):
[In formula, R (1)-R (3) is the same to the description above. ]
So the chemical compound which is displayed and,
The reaction process which reacts with the cyanidation metal
It has, production method.
[claim2]
2. In the aforementioned general system (1) and (3) R (1) and the alkyl group R (2), may be substituted, [shikuroarukiru] which is possible to be substituted, or it is the aryl basis which is possible to be substituted, in claim 1 production method of statement.
[claim3]
3. In the aforementioned general system (1) and (3) R (1) and the alkyl group R (2), may be substituted or it is [shikuroarukiru] which is possible to be substituted, in claim 1 or 2 production method of statement.
[claim4]
4. The aforementioned cyanidation metal is the potassium cyanide, in either of the claim 1-3 production method of statement.
[claim5]
5. In the aforementioned general system (2) R it is the aryl basis (5) and R (8) -R (10), may be substituted, in either of the claim 1-4 production method of statement.
[claim6]
6. In the aforementioned general system (2) R (6), is the primary alkyl group which is substituted with alkoxy group, in either of the claim 1-5 production method of statement.
[claim7]
7. In the aforementioned general system (2) R (10), is the aryl basis which is substituted with the halogenation alkyl group, in either of the claim 1-6 production method of statement.
[claim8]
8. General system (4):
[In formula, R (1)-R (2) is the same to the description above.
X shows the halogen atom. ]
So being production method of the optical active chemical compound which is displayed,
In the optical active chemical compound which in either of the claim 1-7 is obtained with production method of statement - SO [2] R (3) after substituting the basis in the aralkyl basis, the said aralkyl basis - the process which is substituted in the NH [3] X basis
It has, production method.
[claim9]
9. General system (5):
[In formula, R (1)-R (2) is the same to the description above. ]
So being production method of the optical active chemical compound which is displayed,
The process which neutralizes the optical active chemical compound which in claim 8 is obtained with production method of statement
It has, production method.
[claim10]
10. General system (2):
[In formula, R (5) and R (8), -R (10) equality or differing, the alkyl group which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (6) shows the primary alkyl group which is possible to be substituted.
R (7) the aliphatic alkyl group which is possible to be substituted, or [shikuroarukiru] which is possible to be substituted is shown.
X (1) shows the halogen atom or the anion of 1 value. ]
So the catalyst for strike wrecker reaction which consists of the [toriazoriumu] salt which is displayed.
[claim11]
11. In the aforementioned general system (2) R it is the aryl basis (5) and R (8) -R (10), may be substituted, in claim 10 the catalyst of statement.
[claim12]
12. As for the aforementioned strike wrecker reaction,
General system (3):
[In formula, R (1) and R (2) differs, the alkyl group which is possible to be substituted, [shikuroarukiru] which is possible to be substituted, the [arukeniru] basis which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (3) shows the organic basis. ]
So the chemical compound which is displayed and,
Reacting with the cyanidation metal,
General system (1):
[In formula, R (1)-R (3) is the same to the description above. ]
So it is the reaction which obtains the optical active chemical compound which is displayed, in claim 10 or 11 the catalyst of statement.
[claim13]
13. In the aforementioned general system (1) and (3) R (1) and the alkyl group R (2), may be substituted, [shikuroarukiru] which is possible to be substituted, or it is the aryl basis which is possible to be substituted, in claim 12 the catalyst of statement.
[claim14]
14. General system (2A):
[In formula, R (5) and R (8), -R (10) equality or differing, the alkyl group which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (6A) the primary alkyl group which is substituted with alkoxy group is shown.
R (7) the aliphatic alkyl group which is possible to be substituted is shown.
X (1) shows the halogen atom or the anion of 1 value. ]
So the [toriazoriumu] salt which is displayed.
[claim15]
15. In the aforementioned general system (2) R it is the aryl basis (5) and R (8) -R (10), may be substituted, in claim 14 the [toriazoriumu] salt of statement.
[claim16]
16. The description above R (10), is the aryl basis which is substituted with the halogenation alkyl group, in claim 14 or 15 the [toriazoriumu] salt of statement.
[claim17]
17. General system (1A):
[In formula, R (1) and R (2) differs, the alkyl group which is possible to be substituted, [shikuroarukiru] which is possible to be substituted, the [arukeniru] basis which is possible to be substituted, or shows the aryl basis which is possible to be substituted.
R (3A) [jiarukiruhueniru] is shown. ]
So the optical active chemical compound which is displayed.
[claim18]
18. R in the aforementioned general system (1A) (1) and the alkyl group R (2), may be substituted, [shikuroarukiru] which is possible to be substituted, or it is the aryl basis which is possible to be substituted, in claim 17 the optical active chemical compound of statement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGOYA UNIVERSITY
  • 発明者(英語)
  • OOI TAKASHI
  • OHMATSU KOHSUKE
国際特許分類(IPC)
指定国 (WO201706929)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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