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DRUG-CARRYING HYDROGEL FORMULATION AND METHOD FOR PRODUCING SAME

外国特許コード F160008914
整理番号 (S2015-0921-N0)
掲載日 2016年12月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP059515
国際公開番号 WO 2016158707
国際出願日 平成28年3月24日(2016.3.24)
国際公開日 平成28年10月6日(2016.10.6)
優先権データ
  • 特願2015-073019 (2015.3.31) JP
発明の名称 (英語) DRUG-CARRYING HYDROGEL FORMULATION AND METHOD FOR PRODUCING SAME
発明の概要(英語) Provided are a drug-carrying formulation with which it is possible to carry out release with little initial burst, and a method for producing the same. Provided is a method for producing a drug-carrying hydrogel formulation, the method including the following: (a) a step for obtaining a biodegradable polymer gel by crosslinking a biodegradable polymer in an aqueous solution; (b) a step for finely granulating the biodegradable polymer gel; and (c) a step for obtaining a drug-carrying hydrogel by bringing the finely granulated biodegradable polymer gel into contact with a solution that contains a drug.
特許請求の範囲(英語) [claim1]
1. Below:
(A) Building a bridge reacting the biodegradation characteristic macromolecule in the aqueous solution, the process which obtains the biodegradation characteristic high-molecular gel;
(B) The process which the biodegradation characteristic high-molecular gel to fine grain is converted;
And
(C) The to fine grain making with the biodegradation characteristic high-molecular gel which is converted and the solution contact which includes the medicine, the process which obtains medicine support [haidorogeru]
It includes, production method of the medicine support [haidorogeru] formulation.
[claim2]
2. Process (c) afterwards, centrifugal it separates medicine support [haidorogeru], the process which next removes supernatant (c') furthermore it includes, in claim 1 production method of statement.
[claim3]
3. Process (c) after and process (on c') front, the process which it freezes dries medicine support [haidorogeru] (c') furthermore is included, in claim 2 production method of statement.
[claim4]
4. Process (b) after and process (c) before, to fine grain the biodegradation characteristic high-molecular gel which is converted amount the process which works out (b') furthermore it includes the molecular weight and/or due to particle diameter, either of the claim 1-3 in 1 sections production method of statement.
[claim5]
5. The medicine, at least is 1 where it is chosen kinds from the group which consists of [shisupurachin], [karubopurachin], [nedapurachin] and [okisaripurachin], either of the claim 1-4 in 1 sections production method of statement.
[claim6]
6. The biodegradation characteristic macromolecule is the gelatin, either of the claim 1-5 in 1 sections production method of statement.
[claim7]
7. Either of the claim 1-6 it is obtained in 1 sections by the production method of statement, the medicine support [haidorogeru] formulation.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • TSUNODA SHIGERU
  • SAKAI YOSHIHARU
  • TABATA YASUHIKO
  • GUNJI SHUTARO
  • YAMASHITA KOTA
国際特許分類(IPC)
指定国 (WO2016158707)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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