TOP > 外国特許検索 > MEMORY-IMPROVING AGENT AND USE THEREOF

MEMORY-IMPROVING AGENT AND USE THEREOF

外国特許コード F170008917
整理番号 (S2015-0748-N0)
掲載日 2017年1月13日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP062006
国際公開番号 WO 2016167318
国際出願日 平成28年4月14日(2016.4.14)
国際公開日 平成28年10月20日(2016.10.20)
優先権データ
  • 特願2015-084402 (2015.4.16) JP
発明の名称 (英語) MEMORY-IMPROVING AGENT AND USE THEREOF
発明の概要(英語) Provided are: a memory-improving agent and memory-improving composition containing as an active ingredient a compound that is an inverse agonist of opioid δ receptors, a pharmacologically acceptable salt thereof, or a solvate of these; and a compound represented by formula (5), a pharmacologically acceptable salt thereof, or a solvate of these.
特許請求の範囲(英語) [claim1]
1. The chemical compound which is [inbasuagonisuto] of the [opioido] I receptor, it contains the salt or those solvent dishes dressed with sauce which that pharmacy is allowed, as the active ingredient the memory improvement medicine.
[claim2]
2. Aforementioned [inbasuagonisuto], is displayed with the below-mentioned formula (1) is the chemical compound which, in claim 1 the memory improvement medicine of statement.
[Formula (1) in, R (1) may be substituted in each case, the alkyl group of the carbon count 1-5, [shikuroarukiruarukiru] of the carbon count 4-7, [shikuroarukeniruarukiru] of the carbon count 5-7, the aryl basis of the carbon count 6-12, the hetero aryl basis of the carbon count 6-12, the aralkyl basis of the carbon count 7-13, the [arukeniru] basis and the aryl group of the carbon count 4-7, the franc of carbon count 1-5 - 2 - the thiophene of [iruarukiru] and the carbon count 1-5 - 2 - the halogenation alkyl group of [iruarukiru] and the carbon count 1-6, the alkyl carbonyl group of the carbon count 1-6, the [shikuroarukirukaruboniru] basis of the carbon count 1-6, the aryl carbonyl group of the carbon count 7-13, the hetero aryl carbonyl group of the carbon count 6-12 and the aryl alkyl carbonyl group of the carbon count 6-12,To display the hetero aryl alkyl carbonyl group of the carbon count 6-12 and the [arukenirukaruboniru] basis of the carbon count 1-6, R (2) and R (3), in the respective independence, the hydrogen atom, the hydroxy basis and the [arukanoruokishi] basis of the carbon count 1-5, the alkoxy group of the carbon count 1-5, to display the aryl carbonyl oxy basis of the carbon count 7-13 or the aralkyl oxy basis of the carbon count 7-13, as for X, the below-mentioned formula (2)
[Formula (2) in, R (4), the hydrogen atom, to display the alkyl group of the carbon count 1-5 or the aralkyl basis of the carbon count 7-13, R (5), R (6) and R (7), in the respective independence, the hydrogen atom, the fluorine atom, the chlorine atom, the bromine atom and the iodic atom, the nitro group, the [isochioshianato] basis, the trifluoromethyl basis, the [torihuruorometokishi] basis and the cyano basis, phenyl group, the alkyl group of the amino group and the carbon count 1-5, the alkoxy group of the carbon count 1-5, the hydroxy alkyl group of the carbon count 1-3, [shikuroarukiru] of the carbon count 3-7, SR (8), SOR (8), SO [2] R (8), (CH [2]) [M] CO [2] R (8) (however, m integer of the 0-3, R (8) displays the alkyl group of the carbon count 1-5.)SO [2] NR (9) R (10), CONR (9) R (10) or (CH [2]) [n] NR (9) R (10) (however, n integer of the 0-3, R (9), R (10) the hydrogen atom, displays alkyl group of the carbon count 1-5 or [shikuroarukiruarukiru] of the carbon count 4-6 in the respective independence.)Displaying, or or R (7) being the same to the aforementioned definition and, R (5) and connecting R (6), (1) the alkylene basis of the carbon count 3-6 (however, as for the hydrogen of the alkylene section R (11) (R (11) the alkyl group of the carbon count 1-5, the alkoxy group of the carbon count 1-5, the [arukanoiru] basis of the carbon count 1-5, the hydroxy alkyl group of the carbon count 1-5, SR (8), SOR (8), SO [2] R (8), (CH [2]) [m] CO [2] R (8), SO [2] NR (9) R (10)CONR (9) R (10), (CH [2]) [n] NR (9) R (10) (however, m, n and R (8), R (9) and R (10) it is the same to the aforementioned definition.))So it is possible to be substituted, at the same time the alkylene basis connecting to the carbon which benzene ring adjoins, forms ring.)Or (2)-S=T-U=V- (as for S, T, U and V nitrogen atom or CH (however, as for hydrogen atom R (12) (R (12) fluorine atom, chlorine atom, bromine atom and iodic atom, nitro group, [isochioshianato] basis, trifluoromethyl basis, [torihuruorometokishi] basis and cyano basis, alkyl group of phenyl group and carbon count 1-5, alkoxy group of carbon count 1-5, hydroxy alkyl group of carbon count 1-3, SR (8), SOR (8), SO [2] R (8), (CH [2]) [m] CO [2] R (8), SO [2] NR (9) R (10), CONR (9) R (10) or (CH [2]) [n] NR (9) R (10) (however, m, n and R (8), R (9) and R (10) it is the same to the aforementioned definition.))So it is possible to be substituted, connecting to the carbon which at the same time benzene ring adjoins, it forms ring.)You display. ] Or the below-mentioned formula (3)
[Formula (3) in, R (13) and R (14), in the respective independence, the hydrogen atom, the fluorine atom, the chlorine atom and the bromine atom, the nitro group, the alkyl group of the amino group and the carbon count 1-5 or the alkoxy group of the carbon count 1-5 are displayed, or or R (13) and R (14) becomes simultaneous and displays the benzo basis. ] Or the below-mentioned formula (4)
[Formula (4) in, R (5), R (6) and R (7) it is the same to the aforementioned definition. ] You display. ]
[claim3]
3. The description above R (1) may be substituted, in each case, the benzyl basis, the hetero aryl methyl group, the fluoro alkyl group of the carbon count 1-6, it is the [shikuroarukirukaruboniru] basis of the carbon count 1-6, the aryl carbonyl group of the carbon count 7-13 or the hetero aryl carbonyl group of the carbon count 6-12, in claim 1 or 2 the memory improvement medicine of statement.
[claim4]
4. Either of the claim 1-3 the composition for memory improvement which contains the memory improvement medicine of statement and the carrier which is allowed pharmacy in one section.
[claim5]
5. The below-mentioned formula the chemical compound which is displayed with (5), that the salt or those solvent dishes dressed with sauce which is allowed pharmacy.
[Formula (5) in, R (1b), each of them may be substituted, R which displays the alkyl carbonyl group of the carbon count 1-6, the [shikuroarukirukaruboniru] basis of the carbon count 1-6, the aryl carbonyl group of the carbon count 7-13, the hetero aryl carbonyl group of the carbon count 6-12, the aryl alkyl carbonyl group of the carbon count 6-12, the hetero aryl alkyl carbonyl group of the carbon count 6-12 and the [arukenirukaruboniru] basis of the carbon count 1-6 R (2b), R (3b) and X (b), in the respective aforementioned system (1) (2), it is the same to R (3) and X definition. ]
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KITASATO INSTITUTE
  • 発明者(英語)
  • FUJII HIDEAKI
  • HIRAYAMA SHIGETO
  • TANABE MITSUO
  • IWAI TAKASHI
国際特許分類(IPC)
指定国 (WO2016167318)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

PAGE TOP

close
close
close
close
close
close