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GLUCOSE-SENSITIVE CELL PROTECTING AGENT

外国特許コード F170008929
整理番号 (S2015-0924-N0)
掲載日 2017年1月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP060882
国際公開番号 WO 2016159335
国際出願日 平成28年4月1日(2016.4.1)
国際公開日 平成28年10月6日(2016.10.6)
優先権データ
  • 特願2015-077228 (2015.4.3) JP
発明の名称 (英語) GLUCOSE-SENSITIVE CELL PROTECTING AGENT
発明の概要(英語) Provided is a means for reducing adverse effects of a high glucose concentration on the living body. Provided are: a preparation for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the preparation containing N-acetyl-D-mannosamine; a pharmaceutical composition for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the pharmaceutical composition containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier; a use of N-acetyl-D-mannosamine to prepare a drug for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration; and a method for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the method including a step for administering an effective amount of N-acetyl-D-mannosamine to a subject in need thereof. The glucose-sensitive cells are selected from the group consisting of nerve cells, renal cells, and vascular endothelial cells.
特許請求の範囲(英語) [claim1]
1. Containing [N]-ASECHIRU-D-MANNOSAMIN, the medicine in order becomes, to protect the glucose being susceptible sex cell from the glucose virulence due to high glucose density.
[claim2]
2. It is chosen from the group where the glucose being susceptible sex cell consists of the nerve cell, the kidney cell and the blood vessel endotherium, in claim 1 the medicine of statement.
[claim3]
3. It is chosen than the group where the glucose being susceptible sex cell consists of the kidney cell and the blood vessel endotherium, it is the genome restoration protection of the glucose being susceptible sex cell in the particular cell, in claim 1 the medicine of statement.
[claim4]
4. Containing the carrier which can be allowed as the effective quantity and the medicine of [N]-ASECHIRU-D-MANNOSAMIN the medicine composition in order becomes, to protect the glucose being susceptible sex cell from the glucose virulence due to high glucose density.
[claim5]
5. It is chosen from the group where the glucose being susceptible sex cell consists of the nerve cell, the kidney cell and the blood vessel endotherium, in claim 4 the medicine composition of statement.
[claim6]
6. It is chosen than the group where the glucose being susceptible sex cell consists of the kidney cell and the blood vessel endotherium, it is the genome restoration protection of the glucose being susceptible sex cell in the particular cell, in claim 4 the medicine composition of statement.
[claim7]
7. It is something in order to remedy the complication due to diabetes, either of the claim 4-6 in 1 sections the medicine composition of statement.
[claim8]
8. The use of [N]-ASECHIRU-D-MANNOSAMIN in order to produce the medicine for protection of glucose being susceptible sex cell from the glucose virulence due to high glucose density.
[claim9]
9. It is chosen from the group where the glucose being susceptible sex cell consists of the nerve cell, the kidney cell and the blood vessel endotherium, in claim 8 use of statement.
[claim10]
10. It is chosen than the group where the glucose being susceptible sex cell consists of the kidney cell and the blood vessel endotherium, it is the genome restoration protection of the glucose being susceptible sex cell in the particular cell, in claim 8 use of statement.
[claim11]
11. The effective quantity of [N]-ASECHIRU-D-MANNOSAMIN the process which is prescribed to the object which needs that is included, the method the glucose being susceptible sex cell being protected from the glucose virulence due to high glucose density.
[claim12]
12. It is chosen from the group where the glucose being susceptible sex cell consists of the nerve cell, the kidney cell and the blood vessel endotherium, in claim 11 method of statement.
[claim13]
13. It is chosen than the group where the glucose being susceptible sex cell consists of the kidney cell and the blood vessel endotherium, it is the genome restoration protection of the glucose being susceptible sex cell in the particular cell, in claim 11 method of statement.
[claim14]
14. It is something in order it prevents or to remedy the complication due to diabetes, either of the claim 11-13 in 1 sections method of statement.
[claim15]
15. Containing [N]-ASECHIRU-D-MANNOSAMIN, it becomes, the protective agent of the nerve cell disappearance by high glucose density.
[claim16]
16. The nerve cell is the [orekishin] nerve cell, in claim 15 the medicine of statement.
[claim17]
17. Containing the carrier which can be allowed as the effective quantity and the medicine of [N]-ASECHIRU-D-MANNOSAMIN the medicine composition in order becomes, it prevents or to remedy the nerve cell disappearance with high glucose density.
[claim18]
18. The nerve cell is the [orekishin] nerve cell, in claim 17 the medicine composition of statement.
[claim19]
19. It is something in order to remedy the complication due to diabetes, in claim 17 or 18 the medicine composition of statement.
[claim20]
20. The use of [N]-ASECHIRU-D-MANNOSAMIN in order to produce the medicine for protection of nerve cell disappearance by high glucose density.
[claim21]
21. The nerve cell is the [orekishin] nerve cell, in claim 20 use of statement.
[claim22]
22. The effective quantity of [N]-ASECHIRU-D-MANNOSAMIN the process which is prescribed to the object which needs that is included, preventive of the nerve cell disappearance with high glucose density or remedy method.
[claim23]
23. The nerve cell is the [orekishin] nerve cell, in claim 22 method of statement.
[claim24]
24. It is something in order it prevents or to remedy the complication due to diabetes, in claim 22 or 23 method of statement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TOKYO
  • 発明者(英語)
  • SHIOTA KUNIO
  • HAYAKAWA KOJI
  • TAKAMORI MITSUKO
  • FUJII RYOSUKE
  • ITO YUKISHIGE
国際特許分類(IPC)
指定国 (WO2016159335)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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