TOP > 外国特許検索 > SYNOVIAL CELL GROWTH INHIBITOR AND METHOD OF INHIBITING SYNOVIAL CELL GROWTH

SYNOVIAL CELL GROWTH INHIBITOR AND METHOD OF INHIBITING SYNOVIAL CELL GROWTH

外国特許コード F170008943
整理番号 F13089-JP
掲載日 2017年2月1日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP001118
国際公開番号 WO 2015136887
国際出願日 平成27年3月3日(2015.3.3)
国際公開日 平成27年9月17日(2015.9.17)
優先権データ
  • 特願2014-046300 (2014.3.10) JP
発明の名称 (英語) SYNOVIAL CELL GROWTH INHIBITOR AND METHOD OF INHIBITING SYNOVIAL CELL GROWTH
発明の概要(英語) Provided is a synovial cell growth inhibitor which can suitably inhibit growth of synovial cells, and which is characterized by containing formula 1. The endoplasmic reticulum stress response is inhibited, and endoplasmic reticulum stress induces apoptosis in synovial cells, suppressing synovitis. Rheumatoid arthritis destroys joint cartilage, and thus joints, by proteolytic enzymes and cytokine secreted due to abnormal growth of synovial cells. By inhibiting IRE1, transcription and activation of the XBP1 gene are inhibited (the endoplasmic reticulum stress response is inhibited), and by suppressing the ERAD system, apoptosis is induced in synovial cells, suppressing synovial cell growth.
特許請求の範囲(英語) [claim1]
1. Formula 1 or at least either of formula 2 the sliding membrane cell multiplication inhibiter which features that the chemical compound of one side is contained.
[claim2]
2. In the claim 1 which features that it is used for the remedy of joint [riumachi] the sliding membrane cell multiplication inhibiter of statement.
[claim3]
3. In the claim 2 which features that escape phenomenon of the joint [riumachi] remedy is evaded sliding membrane cell multiplication control of statement.
[claim4]
4. Formula 1 or at least either of formula 2 multiplication control method of the sliding membrane cell which features that the medicine which contains the chemical compound of one side is used.
[claim5]
5. Formula 1 or at least either of formula 2 prevention of joint [riumachi] which features that the medicine which contains the chemical compound of one side is used and/or remedy method.
[claim6]
6. In the claim 5 which features that placing the interval of 6 weekly -18 week, it prescribes the aforementioned medicine of 0.01-10mg/mL prevention of joint [riumachi] of statement and/or remedy method.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HIROSHIMA UNIVERSITY
  • 発明者(英語)
  • OCHI MITSUO
  • IZUMI SOUTAROU
国際特許分類(IPC)
指定国 (WO2015136887)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

PAGE TOP

close
close
close
close
close
close