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NOVEL CELL MEMBRANE-PERMEATING PEPTIDE

外国特許コード F170008944
整理番号 (S2015-1544-N0)
掲載日 2017年2月1日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP064767
国際公開番号 WO 2016186140
国際出願日 平成28年5月18日(2016.5.18)
国際公開日 平成28年11月24日(2016.11.24)
優先権データ
  • 特願2015-101497 (2015.5.19) JP
発明の名称 (英語) NOVEL CELL MEMBRANE-PERMEATING PEPTIDE
発明の概要(英語) The present invention addresses the problem of providing a novel membrane permeability-improving agent which can be applied to polymeric drugs. More specifically, the present invention addresses the problem of providing: a drug carrier which can improve the absorption efficiency of a polymeric drug in the small intestine; and a membrane permeation-improving agent containing the carrier. According to the present invention, a cell membrane-permeating peptide can be provided, which comprises an amino acid sequence selected from the group consisting of the following amino acid sequences: an amino acid sequence DNPGN (SEQ ID NO: 1); an amino acid sequence SRPAF (SEQ ID NO: 2); an amino acid sequence NDPRN (SEQ ID NO: 3); and an amino acid sequence MSVAN (SEQ ID NO: 4). According to the present invention, a cell membrane-permeating composition can also be provided, which comprises the peptide and a physiologically active substance.
特許請求の範囲(英語) [claim1]
1. The below-mentioned amino acid arrangement: Amino acid arrangement DNPGN (SEQ ID NO 1), SRPAF (SEQ ID NO 2), NDPRN (SEQ ID NO 3), and MSVAN (SEQ ID NO 4) from the group which consists of the cell membrane permeable peptide which includes the amino acid arrangement which is chosen.
[claim2]
2. In the claim 1 which at least includes one non natural type amino acid the cell membrane permeable peptide of statement.
[claim3]
3. The aforementioned peptide, amino acid arrangement DNPGNET (SEQ ID NO 5), TVSRPAF (SEQ ID NO 6), HSNDPRN (SEQ ID NO 7), and PFMSVAN (SEQ ID NO 8) from the group which consists of in the claim 1 which includes the amino acid arrangement which is chosen or 2 the cell membrane permeable peptide of statement.
[claim4]
4. The aforementioned peptide, amino acid arrangement DNPGN (SEQ ID NO 1) or DNPGNE (SEQ ID NO 9) in the claim 1 which is included or 2 the cell membrane permeable peptide of statement.
[claim5]
5. Either of the claim 1-4 where the aforementioned peptide is annular peptide in one the cell membrane permeable peptide of statement.
[claim6]
6. It is the annular peptide to which the aforementioned annular peptide includes Cys-Cys disulfide bond, in claim 5 the cell membrane permeable peptide of statement.
[claim7]
7. The aforementioned peptide, either of the claim 1-6 which is the peptide which transmits the small intestine epithelium cell of the mammal cell in one the cell membrane permeable peptide of statement.
[claim8]
8. The below-mentioned amino acid arrangement: DNPGN (SEQ ID NO 1), SRPAF (SEQ ID NO 2), NDPRN (SEQ ID NO 3), and MSVAN (SEQ ID NO 4) being the peptide which includes the amino acid arrangement which is chosen, and the composition which includes the bioactive substance from the group which consists of, as for the said peptide, the active material carrier and the composition which is the cell membrane permeability which forms the connection or the said bioactive substance or the said bioactive substance is included mixture.
[claim9]
9. The aforementioned peptide, in the claim 8 which at least includes one non natural type amino acid the composition of statement.
[claim10]
10. The aforementioned peptide, amino acid arrangement DNPGNET (SEQ ID NO 5), TVSRPAF (SEQ ID NO 6), HSNDPRN (SEQ ID NO 7), and PFMSVAN (SEQ ID NO 8) from the group which consists of in the claim 8 which includes the amino acid arrangement which is chosen or 9 the composition of statement.
[claim11]
11. The aforementioned peptide, amino acid arrangement DNPGN (SEQ ID NO 1) or DNPGNE (SEQ ID NO 9) in the claim 8 which is included or 9 the composition of statement.
[claim12]
12. Either of the claim 8-11 where the aforementioned peptide is annular peptide in one the composition of statement.
[claim13]
13. It is the annular peptide to which the aforementioned annular peptide includes Cys-Cys disulfide bond, in claim 12 the composition of statement.
[claim14]
14. Either of the claim 8-13 to which the aforementioned bioactive substance includes the macromolecule in one the composition of statement.
[claim15]
15. The aforementioned macromolecule, in the claim 14 which includes physiological active peptide or the protein the composition of statement.
[claim16]
16. In the claim 15 where the aforementioned physiological active peptide is the insulin the composition of statement.
[claim17]
17. In the claim 14 to which the aforementioned macromolecule includes nuclear acid the composition of statement.
[claim18]
18. The aforementioned nuclear acid, in the claim 17 which is anti sense DNA, siRNA or shRNA the composition of statement.
[claim19]
19. The active material carrier which includes the aforementioned bioactive substance, either of the claim 8-18 which is the liposome in one the composition of statement.
[claim20]
20. The active material carrier which includes the aforementioned bioactive substance, either of the claim 8-18 which is [shikurodekisutorin] in one the composition of statement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • ITO SHINGO
  • OHTSUKI SUMIO
国際特許分類(IPC)
指定国 (WO2016186140)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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