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EVALUATION OF INHIBITORY CIRCUIT AND USE THEREOF

外国特許コード F170008950
整理番号 (S2015-1410-N0)
掲載日 2017年2月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP068144
国際公開番号 WO 2016204282
国際出願日 平成28年6月17日(2016.6.17)
国際公開日 平成28年12月22日(2016.12.22)
優先権データ
  • 特願2015-122657 (2015.6.18) JP
発明の名称 (英語) EVALUATION OF INHIBITORY CIRCUIT AND USE THEREOF
発明の概要(英語) Provided are a more practical method of evaluating an inhibitory circuit applicable to a living body and the use thereof. Herein the action of an inhibitory circuit on an excitatory circuit is evaluated on the basis of attenuation of the brain activity produced by activation of an excitatory circuit by the input of an inhibitory circuit by performing a step for inputting an inhibitory circuit by applying a second trigger in advance of a first trigger to an excitatory circuit activated by a first trigger which is a stimulus or challenge.
特許請求の範囲(英語) [claim1]
1. Being the detection system of the suppression circuit of the brain,
The detection device which detects brain activity and,
The 2nd origination which has the possibility of changing the 1st brain activity which it occurs with the input of 1st origination and the aforementioned 1st origination which are stimulus or the topic for the organism and, the origination output device which is granted and,
The expedient which acquires the information of the 1st brain activity regarding the aforementioned 1st brain activity and,
The expedient which acquires the information of the 2nd brain activity regarding the 2nd brain activity which it occurs with the grant of the aforementioned 1st origination which accompanies the grant of the aforementioned 2nd origination and,
On the basis of the information of the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity the expedient which detects the response in 1st brain being active which it occurs with the grant of the aforementioned 2nd origination and,
It has, the system which detects the suppression circuit of the brain on the basis of the response of the aforementioned brain activity.
[claim2]
2. Furthermore, the expedient which executes the output process of the information regarding the aforementioned suppression circuit, it has, in claim 1 the system of statement.
[claim3]
3. Information of the aforementioned 1st brain activity is the information regarding the response circuit for the change of origination, in claim 1 or 2 the system of statement.
[claim4]
4. Information of the aforementioned 1st brain activity, tactual sense and thermesthesia, the somatic feeling which is pain and deep feeling, is the information regarding the response circuit regarding 1 kinds or 2 kinds or more which are selected from the group which consists of eyesight, hearing, the sense of taste and the olfactory sense, in either of the claim 1-3 the system of statement.
[claim5]
5. Information of the aforementioned 1st brain activity is the information regarding the excitability circuit, in either of the claim 1-4 the system of statement.
[claim6]
6. Information of the aforementioned 1st brain activity is the information regarding the response circuit regarding hearing, in either of the claim 1-5 the system of statement.
[claim7]
7. Information of the aforementioned 1st brain activity is the information regarding the response circuit for sound pressure change, in claim 6 the system of statement.
[claim8]
8. The aforementioned suppression circuit is both parties or one side of the GABA-A inclusion suppression circuit and the GABA-B inclusion suppression circuit, in either of the claim 1-7 the system of statement.
[claim9]
9. Preceding the grant of the aforementioned 1st origination in the range below 1 milli-second or more 5000 milli-seconds, it executes the grant of the aforementioned 2nd origination, in either of the claim 1-8 the system of statement.
[claim10]
10. Below 5 milli-second or more 60 milli-seconds and either below 500 milli-second or more 700 milli-seconds or preceding the grant of the aforementioned 1st origination in the both ranges, it executes the grant of the aforementioned 2nd origination, in either of the claim 1-9 the system of statement.
[claim11]
11. Furthermore, the expedient which appraises the action of the aforementioned suppression circuit on the basis of with the information of the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, is had, in either of the claim 1-10 the system of statement.
[claim12]
12. The aforementioned detection device detects the aforementioned brain activity with the electric activity which is based on brain activity, in either of the claim 1-11 the system of statement.
[claim13]
13. The aforementioned detection device detects the aforementioned brain activity making use of the electroencephalogram or brain magnetic figure, in either of the claim 1-12 the system of statement.
[claim14]
14. The description above 2nd origination the description above 1st origination compared to is origination of low intensity, in either of the claim 1-13 the system of statement.
[claim15]
15. Response of the aforementioned brain activity is attenuation of the aforementioned brain activity, in either of the claim 1-14 the system of statement.
[claim16]
16. Being operation method of the detection system of the suppression circuit of the brain,
As for the aforementioned detection system, the origination output device which grants the 2nd origination which has the possibility of changing the 1st brain activity which it occurs with the grant of 1st origination and the aforementioned 1st origination which are stimulus or the topic for the aforementioned organism vis-a-vis the detection device and the organism which detect brain activity, and, having,
The process which acquires the information of the 1st brain activity regarding the aforementioned 1st brain activity and,
The process which acquires the information of the 2nd brain activity regarding the 2nd brain activity which it occurs with the grant of the aforementioned 1st origination which accompanies the grant of the aforementioned 2nd origination and,
On the basis of the information of the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity the process which detects the response in the aforementioned 1st brain being active which it occurs with the grant of the aforementioned 2nd origination and,
It has, operation method of the system which detects the suppression circuit of the brain on the basis of the response of the aforementioned brain activity.
[claim17]
17. Being analysis method of the suppression circuit of the brain,
The 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants to the suffering *** body and,
The process which acquires the information of the 2nd brain activity regarding the 2nd brain activity which it occurs with the grant of the aforementioned 1st origination which accompanies the grant of the aforementioned 2nd origination and,
The process which acquires the response in 1st brain being active which it occurs on the basis of with the information of the 1st brain activity regarding the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
It has, analysis method.
[claim18]
18. Being inspection method of the disease regarding the suppression circuit,
The 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants to the suffering *** body, having,
The aforementioned suppression circuit is appraised on the basis of the response in 1st brain being active which it occurs with the grant of the aforementioned 2nd origination, method.
[claim19]
19. Being evaluation method of the medicine which is used for the disease regarding the suppression circuit,
In the suffering *** body where the aforementioned medicine is not prescribed, the 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants and,
In the aforementioned suffering *** body which prescribes the aforementioned medicine, the 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants and,
Having,
The aforementioned suffering *** body where the aforementioned medicine is not prescribed and the aforementioned suffering *** body where the aforementioned medicine is prescribed in respectively, effectiveness of the aforementioned medicine is appraised on the basis of the response in 1st brain being active which it occurs with the grant of the aforementioned 2nd origination, method.
[claim20]
20. Being screening method of the medicine which is used for the disease regarding the suppression circuit,
In the suffering *** body where the aforementioned medicine is not prescribed, the 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants and,
In the aforementioned suffering *** body which prescribes the aforementioned medicine, the 1st origination which is stimulus or the topic for the organism, accompanying the 2nd origination which has the possibility of changing the 1st brain activity which causes with the grant of the aforementioned 1st origination the process which it grants and,
Having,
The aforementioned suffering *** body where the aforementioned medicine is not prescribed and the aforementioned suffering *** body where the aforementioned medicine is prescribed in respectively, the aforementioned medicine the screening is done on the basis of the response in 1st brain being active which it occurs with the grant of the aforementioned 2nd origination, method.
[claim21]
21. Being the selection system of the medicine candidacy which is applied to the disease regarding the suppression circuit,
The detection device which detects brain activity and,
The origination output device which grants the 2nd origination which has the possibility of changing the 1st brain activity which it occurs with the grant of 1st origination and the aforementioned 1st origination which are stimulus or the topic for the organism and,
The expedient which acquires the information of the 1st brain activity regarding the aforementioned 1st brain activity and,
The expedient which acquires the information of the 2nd brain activity regarding the 2nd brain activity which it occurs with the grant of the aforementioned 1st origination which accompanies the grant of the aforementioned 2nd origination and,
The expedient which acquires the response in 1st brain being active which it occurs on the basis of the information of the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
The expedient which acquires the suppression circuit quality of the suffering *** body on the basis of the response of the aforementioned brain activity and,
It has, the system which selects the medicine candidacy which is applied to the suffering inspection body on the basis of the aforementioned suppression circuit quality.
[claim22]
22. Being selection method of the medicine candidacy which is used for the disease regarding the suppression circuit,
Accompanying the 2nd origination which has the possibility of changing the 1st brain activity which it occurs the 1st origination which is stimulus or the topic for the organism, with the grant of the aforementioned 1st origination granting to the suffering *** body, the process which acquires the information of the 2nd brain activity regarding the 2nd brain activity which can and,
The process which acquires the response in 1st brain being active which it occurs on the basis of the information of the 1st brain activity regarding the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
The process which acquires the suppression circuit quality of the suffering *** body on the basis of the response of the aforementioned brain activity and,
It has, selection method of the medicine candidacy which is applied to the suffering inspection body on the basis of the aforementioned suppression circuit quality.
[claim23]
23. Being production method of the product which utilizes the quality of the suppression circuit,
Accompanying the 2nd origination which has the possibility of changing the 1st brain activity which it occurs the 1st origination which is stimulus or the topic for the organism, with the grant of the aforementioned 1st origination granting to the suffering *** body, the process which acquires the information of the 2nd brain activity regarding the 2nd brain activity which can and,
The process which acquires the response in 1st brain being active which it occurs on the basis of the information of the 1st brain activity regarding the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
The process which acquires the suppression circuit quality of the suffering *** body on the basis of the response of the aforementioned brain activity and,
Having,
On the basis of the aforementioned suppression circuit quality, it conforms to the aforementioned suppression circuit quality, improves, eases, or it produces the product which possesses reinforcement possible function, method.
[claim24]
24. The aforementioned product is the product which it is related to the sensuous action of the person, in claim 23 production method of statement.
[claim25]
25. The aforementioned product conforms to the aforementioned suppression circuit quality regarding the eyesight of the suffering *** body, improves, eases, or it is the product which possesses the sensuous action which is reinforced, in claim 23 or 24 production method of statement.
[claim26]
26. Being the manufacturing system of the product which utilizes the quality of the suppression circuit,
The detection device which detects brain activity and,
The origination output device which grants the 2nd origination which has the possibility of changing the 1st brain activity which it occurs with the grant of 1st origination and the aforementioned 1st origination which are stimulus or the topic for the organism and,
The expedient which acquires the information of the 1st brain activity regarding the aforementioned 1st brain activity and,
The expedient which acquires the information of the 2nd brain activity regarding the 2nd brain activity which it occurs with the grant of the aforementioned 1st origination which accompanies the grant of the aforementioned 2nd origination and,
The expedient which acquires the response in 1st brain being active which it occurs on the basis of the information of the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
The expedient which acquires the suppression circuit quality of the suffering *** body on the basis of the response of the aforementioned brain activity and,
It has, it conforms to the aforementioned suppression circuit quality on the basis of the aforementioned suppression circuit quality, improves, eases, or it produces the product which possesses reinforcement possible function, the system.
[claim27]
27. Being production method of the spectacle lens which utilizes the quality of the suppression circuit,
Accompanying the 2nd origination which has the possibility of changing the 1st brain activity which it occurs the 1st origination which is stimulus or the topic for the organism, with the grant of the aforementioned 1st origination granting to the suffering *** body, the process which acquires the information of the 2nd brain activity regarding the 2nd brain activity which can and,
The process which acquires the response in 1st brain being active which it occurs on the basis of the information of the 1st brain activity regarding the aforementioned 1st brain activity and the information of the aforementioned 2nd brain activity, with the grant of the aforementioned 2nd origination and,
The process which acquires the suppression circuit quality of the suffering *** body on the basis of the response of the aforementioned brain activity and,
Having,
On the basis of the aforementioned suppression circuit quality, it conforms to the aforementioned suppression circuit quality, improves, eases, or it produces the product which possesses reinforcement possible function, method.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
  • TOKAI OPTICAL CO., LTD.
  • 発明者(英語)
  • INUI KOJI
  • TAKESHIMA YASUYUKI
  • SUZUKI MASAYA
  • KUMAGAI NAOYA
国際特許分類(IPC)
指定国 (WO2016204282)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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