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SIMPLE TEST FOR PERIODONTAL DISEASE USING FLUORESCENT DYE

外国特許コード F170008951
整理番号 (S2015-1641-N0)
掲載日 2017年2月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP068991
国際公開番号 WO 2017002754
国際出願日 平成28年6月27日(2016.6.27)
国際公開日 平成29年1月5日(2017.1.5)
優先権データ
  • 特願2015-129848 (2015.6.29) JP
発明の名称 (英語) SIMPLE TEST FOR PERIODONTAL DISEASE USING FLUORESCENT DYE
発明の概要(英語) The present invention provides: a diagnostic drug which can detect a disease associated with the increase in the concentration of methylmercaptan in the oral cavity, e.g., periodontal disease, simply and with high sensitivity; a kit including the diagnostic drug; and a diagnosis method using the diagnostic drug. Specifically, the present invention provides: a diagnostic drug for use in a test for a disease associated with the increase in the concentration of methylmercaptan in the oral cavity in a subject, said diagnostic drug comprising a compound represented by formula I [wherein R1, R2, R3 and R4 independently represent a substituent such as a hydrogen atom; R5 represents an alkenyl group which may be substituted; and X represents O or S], or an isomer of the compound, or a pharmaceutically acceptable salt, a hydrate or a solvate of the compound or the isomer; a kit including the diagnostic drug; and a diagnosis method using the diagnostic drug.
特許請求の範囲(英語) [claim1]
1. Formula I:
I
[In formula,
R (1), R (2), R (3), and, R (4) is selected hydrogen, cyano, hydroxy and nitro, the amino which is possible to be substituted, the alkyl which is possible to be substituted, [shikuroarukiru] which is possible to be substituted, [heteroshikuroarukiru] which is possible to be substituted, the alkoxy which is possible to be substituted, the aryl which is possible to be substituted, and becoming independent from the group which consists of the hetero aryl which is possible to be substituted respectively;
R (5) is [arukeniru] which is possible to be substituted;
X is O or S]
The diagnostic medicine for inspecting the disease which brings the rise of methyl mercaptan density inside the buccal cavity which so chemical compound, or the isomer which are shown, or the salt which that medicine is allowed, includes the hydrate, or the solvent dishes dressed with sauce, in the subject.
[claim2]
2. X is O, in claim 1 the diagnostic medicine of statement.
[claim3]
3. R (1), R (2), R (3), and R (4) hydrogen, cyano, C where it is possible to be substituted [1] - C [6] alkyl, C where it is possible to be substituted [1] - C [6] alkoxy, and becoming independent from the group which consists of the single cyclic type or two cyclic aryls of the 6-10 member who is possible to be substituted respectively, it is selected, in claim 1 or 2 the diagnostic medicine of statement.
[claim4]
4. R (1), R (2), R (3), and R (4) is hydrogen, either of the claim 1-3 in 1 sections the diagnostic medicine of statement.
[claim5]
5. C R (5) may be substituted [2] - it is C [12] [arukeniru], either of the claim 1-4 in 1 sections the diagnostic medicine of statement.
[claim6]
6. R (5) the below-mentioned formula:
[In formula, the wave ray shows the joining consent of the remainder of the molecule]
It is shown by structure, either of the claim 1-5 in 1 sections the diagnostic medicine of statement.
[claim7]
7. Chemical compound the below-mentioned formula:
It is shown by structure, in claim 1 the diagnostic medicine of statement.
[claim8]
8. The disease the tooth lap the illness, the [u] , the bad breath, the stomatitis, the buccal cavity cancer, the blood disease and the heart blood vessel disease, metabolism obstacle, the breathing apparatus disease, is selected from the group which consists of the bone disease, and the necrosis characteristic soft organizational disease, either of the claim 1-7 in 1 sections the diagnostic medicine of statement.
[claim9]
9. The disease the tooth lap is selected from the group which consists of the illness and the bad breath, either of the claim 1-8 in 1 sections the diagnostic medicine of statement.
[claim10]
10. Density of methyl mercaptan is below 20ppb, either of the claim 1-9 in 1 sections the diagnostic medicine of statement.
[claim11]
11. Either of claim 1-10 in 1 sections diagnostic medicine of statement;
The medium which can absorb the suffering *** sample, or contact with the suffering *** sample;
Instruction for use;
As needed base;
And
The additive which as needed is allowed medicine
The kit which is included.
[claim12]
12. The suffering *** sample is the breath or buccal cavity liquid, in claim 11 the kit of statement.
[claim13]
13. Medium the buff solution, is the atmosphere, the active carbon or the solid film, in claim 11 or 12 the kit of statement.
[claim14]
14. Formula:
The diagnostic medicine which includes the chemical compound which is shown by;
The active carbon which was processed with potassium hydroxide;
Instruction for use;
As needed, tetramethyl guanidine;
And
The additive which as needed is allowed medicine
The kit which is included.
[claim15]
15. (i) Either of the claim 1-10 in 1 sections the diagnostic medicine of statement and the process which makes the suffering *** sample contact under existing of as needed base;
And
(ii) The process which inspects the methyl mercaptan in the suffering *** sample by producing the ultraviolet ray making use of the ULTRAVIOLET RADIATION equipment, inspect the extent of change of fluorescent color,
Diagnostic method of the disease which brings the rise of methyl mercaptan density inside the buccal cavity which it includes, in the subject.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKUSHIMA UNIVERSITY
  • 発明者(英語)
  • NAMBA KOSUKE
  • NAKAYAMA ATSUSHI
  • OTANI AKIRA
国際特許分類(IPC)
指定国 (WO201702754)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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