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SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS UPDATE

外国特許コード F170009026
整理番号 (S2015-2042-N0)
掲載日 2017年3月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP077475
国際公開番号 WO 2017047762
国際出願日 平成28年9月16日(2016.9.16)
国際公開日 平成29年3月23日(2017.3.23)
優先権データ
  • 特願2015-185988 (2015.9.18) JP
発明の名称 (英語) SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS UPDATE
発明の概要(英語) The purpose of the present invention is to obtain a novel treatment drug for a malignant tumor or fibrosis. The present invention uses the compounds expressed in formula (1), or salts thereof, or solvates thereof. Or, the present invention uses a treatment drug for a malignant tumor or a treatment drug for fibrosis that includes the compounds expressed in formula (1), or salts thereof, or solvates thereof.
特許請求の範囲(英語) [claim1]
1. The below-mentioned formula chemical compound, that salt, or those solvent dishes dressed with sauce which show in (1):
(In formula, description below (a) or (b) it means substituent R1 and R2.
(A) As for R1, the phenyl which is possible to be substituted;
As for R2, H and - C (O) NHR3, the phenyl which is possible to be substituted;
And
The description above R3, H, C1-C6 alkyl, the benzyl which is possible to be substituted;
Or
(B) As for R1, the naphthyl which is possible to be substituted, or the phenyl which is possible to be substituted;
As for R2, - C (O) NHR4, the phenyl which is possible to be substituted;
And
The description above R4, H, C1-C6 alkyl, [shirokishibenjiru] which is possible to be substituted.)
[claim2]
2. The description above (a) R1 is the phenyl which possesses substituent R5,
The description above R5, H and halogen, nitro and amino, cyano, OH, is the substituent of 1 kinds or more which are chosen from the group which consists of C1-C6 alkyl, halogeno C1-C6 alkyl, hydroxy C1-C6 alkyl, C1-C6 alkyl amino, the C1-C6 alkoxy, the halogeno C1-C6 alkoxy, the hydroxy C1-C6 alkoxy, and C1-C6 alkoxy amino,
The description above (a) R2, H and - C (O) is the phenyl which possesses NHR3 or substituent R5,
The description above R3 is the benzyl which possesses substituent R6,
The description above R6, H and halogen, nitro and amino, cyano, OH, the C1-C6 alkoxy, [tori] C1-C6 [arukirushirokishi] C1-C6 alkyl, C1-C6 [arukirujihuenirushirokishi] C1-C6 alkyl and the [torihuenirushirokishi] C1-C6 alkyl which are substituted with the C1-C6 alkoxy and the C1-C6 alkoxy phenyl which are substituted with C1-C6 alkyl, halogeno C1-C6 alkyl, hydroxy C1-C6 alkyl, C1-C6 alkyl amino, the C1-C6 alkoxy, the halogeno C1-C6 alkoxy, the hydroxy C1-C6 alkoxy, C1-C6 alkoxy amino and the C1-C6 alkoxy, [tori] C1-C6 [arukirushirokishi], is the substituent of 1 kinds or more which are chosen from C1-C6 [arukirujihuenirushirokishi], and the group which consists of [torihuenirushirokishi],
The description above (b) R1, is phenyl or the naphthyl which possesses substituent R5,
The description above (b) R2 - C (O) to be the phenyl which possesses NHR4 or substituent R5, at the same time
The description above R4, H, C1-C6 alkyl, is [shirokishibenjiru] which possesses substituent R5,
In claim 1 chemical compound of statement, that salt, or those solvent dishes dressed with sauce.
[claim3]
3. The description above (a) R2 is - C (O) NH (CH2C6H5),
The description above (b) R1 is naphthyl,
The description above (b) R2, - C (O) to be NHR4, or nitro phenyl, at the same time
The description above R4 is [shirokishibenjiru] which possesses H or substituent R5,
In claim 2 chemical compound of statement, that salt, or those solvent dishes dressed with sauce.
[claim4]
4. The description above (a) R1 is the phenyl which possesses the substituent of 1 kinds or more which are chosen from the group which consists of F, Cl, nitro, OH, and the methoxy,
The description above (a) R2 is - C (O) NH (CH2C6H5),
The description above (b) R1 to be naphthyl, at the same time
The description above (b) R2, - C (O) NH2, is nitro phenyl, or [tert]-buchirujimechirushirokishibenjiru,
To claim 1-3 in each case chemical compound of statement, that salt, or those solvent dishes dressed with sauce.
[claim5]
5. The chemical compound of statement, that salt, or those solvent dishes dressed with sauce is included in either of the claim 1-4, the remedy of the malignant tumor.
[claim6]
6. The chemical compound of statement, that salt, or those solvent dishes dressed with sauce is included in either of the claim 1-4, the remedy of the tissue symptom.
[claim7]
7. The chemical compound of statement, that salt, or those solvent dishes dressed with sauce is included in either of the claim 1-4, the differentiation induction medicine to the liver cell of the mesenchyme type trunk cell.
[claim8]
8. Chemical compound, that salt, or those solvent dishes dressed with sauce which show in the below-mentioned formula (2) are included, the remedy of the malignant tumor which is used chemical compound, in that salt, or those solvent dishes dressed with sauce and 5-FU which are shown in the below-mentioned formula (2) the combined use medical therapy.
(In formula,
R7, and R8, equality or differing, the C1-C6 alkyl which is possible to be substituted, or are C2-C6 [arukeniru] which is possible to be substituted.)
[claim9]
9. 5-FU is included, the remedy of the malignant tumor which is used 5-FU and in chemical compound, that salt, or the combined use medical therapy of those solvent dishes dressed with sauce which are shown in the below-mentioned formula (2).
(In formula,
R7, and R8, equality or differing, the C1-C6 alkyl which is possible to be substituted, or are C2-C6 [arukeniru] which is possible to be substituted.)
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOTTORI UNIVERSITY
  • 発明者(英語)
  • SHIOTA GOSHI
  • ITABA NORIKO
  • MORIMOTO MINORU
  • OKA HIROYUKI
  • ABE KENICHIRO
  • SHIMIZU HIROKI
  • KOUNO YOHEI
  • YOKOGI SATOSHI
国際特許分類(IPC)
指定国 (WO201747762)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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