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SUGAR-SENSING EPIGENOME BIOMARKER

外国特許コード F170009029
整理番号 (S2015-2043-N0)
掲載日 2017年3月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP076497
国際公開番号 WO 2017043593
国際出願日 平成28年9月8日(2016.9.8)
国際公開日 平成29年3月16日(2017.3.16)
優先権データ
  • 特願2015-177176 (2015.9.9) JP
発明の名称 (英語) SUGAR-SENSING EPIGENOME BIOMARKER
発明の概要(英語) An antibody of the present invention specifically bonds to a serine 40 residue modified with N-acetylglucosamine (GlcNAc) in a histone H2A protein. The present invention provides a method for detecting GlcNAc-modification of a serine 40 residue in a histone H2A protein, said method having a step for measuring the level of GlcNAc-modification of the serine 40 residue in the histone H2A protein using the antibody. A protein or a peptide marker of the present invention is a marker for monitoring histone modification caused by fluctuations in the concentration of extracellular glucose, said marker comprising an H2A protein, or a peptide fragment thereof, that contains a GlcNAc-modified serine 40 residue.
特許請求の範囲(英語) [claim1]
1. The [N]-asechiru glucosamine of the histone H2A protein (GlcNAc) the antibody which features that it connects to the ceric 40 residues which are converted uniquely.
[claim2]
2. In claim 1 method of detection of GlcNAc converting the ceric 40 residues of the histone H2A protein which features that the process which measures the GlcNAc conversion level of the ceric 40 residues of the histone H2A protein making use of the antibody of statement, is had.
[claim3]
3. Being screening method of the inhibiter or the activator of GlcNAc conversion of the ceric 40 residues of the histone H2A protein,
In under existing of the suffering *** substance and under non existing, the process which measures the histone H2A protein or the GlcNAc conversion level of the ceric 40 residues of the peptide fragment and,
The aforementioned GlcNAc conversion level under existing of the suffering inspection substance, the aforementioned GlcNAc level which when it is low by comparison with the aforementioned GlcNAc conversion level under non existing of the suffering inspection substance, as for the aforementioned suffering inspection substance that it is the inhibiter of GlcNAc conversion of the ceric 40 residues of the histone H2A protein, it decides, under existing of the suffering inspection substance, when it is high by comparison with the aforementioned phosphorylation level under non existing of the suffering inspection substance, as for the aforementioned suffering inspection substance the process which it decides that it is the activator of GlcNAc conversion of the ceric 40 residues of the histone H2A protein, and,
The screening method of featuring that it has.
[claim4]
4. In under existing of glucose, in the claim 3 which does the aforementioned measurement process screening method of statement.
[claim5]
5. In the claim 3 which does the aforementioned measurement process under the condition which gives the damage to DNA, or 4 screening method of statement.
[claim6]
6. The aforementioned histone H2A protein or GlcNAc conversion level of the ceric 40 residues of the peptide fragment, either of the claim 3-5 which is measured to GlcNAc of the histone H2A protein by the antibody which is connected to the ceric 40 residues which are converted uniquely in one section screening method of statement.
[claim7]
7. Being the method of monitoring the histone decoration which fluctuation of glucose density outside the cell causes,
The method of featuring that the process which measures the GlcNAc conversion level of the ceric 40 residues of the histone H2A protein which existence and depend of glucose it occurs is had.
[claim8]
8. GlcNAc conversion level of the ceric 40 residues of the aforementioned histone H2A protein, in the claim 7 which is measured to GlcNAc of the histone H2A protein by the antibody which is connected to the ceric 40 residues which are converted uniquely method of statement.
[claim9]
9. Being the marker which monitors the histone decoration which fluctuation of glucose density outside the cell causes,
The protein or peptide marker which features that to GlcNAc it includes the ceric 40 residues which are converted, consists of the H2A protein or the peptide fragment.
[claim10]
10. Being the method of appraising the stability of the genome DNA due to [epijieneteikusu] decoration,
The method of featuring that the process which measures the histone H2A protein or the GlcNAc conversion level of the ceric 40 residues of the peptide fragment is had.
[claim11]
11. The aforementioned histone H2A protein or GlcNAc conversion level of the ceric 40 residues of the peptide fragment, in the claim 10 which is measured to GlcNAc of the histone H2A protein by the antibody which is connected to the ceric 40 residues which are converted uniquely method of statement.
[claim12]
12. Being the marker which detects the stability of the genome DNA due to [epijieneteikusu] decoration,
The protein or peptide marker which features that to GlcNAc it includes the ceric 40 residues which are converted, consists of the H2A protein or the peptide fragment.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TOKYO
  • 発明者(英語)
  • SHIOTA KUNIO
  • TAKAMORI MITSUKO
  • HAYAKAWA KOJI
国際特許分類(IPC)
指定国 (WO201743593)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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