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INHIBITORS FOR METHYLATION-RELATED ENZYMES HAT1 AND KAT8

外国特許コード F170009081
整理番号 (S2016-0067-N0)
掲載日 2017年5月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP081939
国際公開番号 WO 2017073692
国際出願日 平成28年10月27日(2016.10.27)
国際公開日 平成29年5月4日(2017.5.4)
優先権データ
  • 特願2015-215267 (2015.10.30) JP
発明の名称 (英語) INHIBITORS FOR METHYLATION-RELATED ENZYMES HAT1 AND KAT8
発明の概要(英語) Provided are a new therapeutic drug for malignant tumors, a method for producing stem cells, a DNA damage-improving agent, or the like. HAT1 and KAT8 inhibitors are used. Alternatively, a kit including a HAT1 inhibitor and a KAT8 inhibitor may be used. Alternatively, a composition containing a HAT1 inhibitor, the HAT1 inhibitor being used in combination with a KAT8 inhibitor, may be used. Alternatively, a composition containing a KAT8 inhibitor, the KAT8 inhibitor being used in combination with a HAT1 inhibitor, may be used.
特許請求の範囲(英語) [claim1]
1. HAT1 and the KAT8 inhibiter are included, the remedy of the malignant tumor.
[claim2]
2. The inhibiter is the RNAi molecule or low-molecular chemical compound, in claim 1 the remedy of statement.
[claim3]
3. The description above HAT1 is the HAT1 gene or the protein, the description above KAT8 is the KAT8 gene or the protein, in claim 1 or 2 the remedy of statement.
[claim4]
4. The aforementioned inhibiter is the inhibiter which obstructs the revelation or function of the HAT1 gene and the KAT8 gene, to claim 1-3 in each case the remedy of statement.
[claim5]
5. The aforementioned inhibiter induces trunk characteristic conversion, to claim 1-4 in each case the remedy of statement.
[claim6]
6. The aforementioned inhibiter contains the HAT1 inhibiter and the KAT8 inhibiter, to claim 1-5 in each case the remedy of statement.
Remedy.
[claim7]
7. The HAT1 inhibiter and the KAT8 inhibiter are included, the kit for remedy of malignant tumor.
[claim8]
8. The HAT1 inhibiter is contained, it can use with the KAT8 inhibiter and the HAT1 inhibiter with combined use, the remedy of the malignant tumor.
[claim9]
9. The KAT8 inhibiter is contained, it can use with the HAT1 inhibiter and the KAT8 inhibiter with combined use, the remedy of the malignant tumor.
[claim10]
10. The process which obstructs HAT1 and KAT8 is included, production method of the trunk cell.
[claim11]
11. The aforementioned obstruction is the gene revelation of HAT1 and KAT8 or obstruction of function, in claim 10 production method of statement.
[claim12]
12. HAT1 and the KAT8 inhibiter are included, the trunk characteristic conversion induction medicine.
[claim13]
13. The HAT1 inhibiter and the KAT8 inhibiter are included, the kit for trunk characteristic conversion induction.
[claim14]
14. The HAT1 inhibiter is contained, it can use with the KAT8 inhibiter and the HAT1 inhibiter with combined use, the trunk characteristic conversion induction medicine.
[claim15]
15. The KAT8 inhibiter is contained, it can use with the HAT1 inhibiter and the KAT8 inhibiter with combined use, the trunk characteristic conversion induction medicine.
[claim16]
16. HAT1 and the KAT8 inhibiter are included, the DNA damage improvement medicine.
[claim17]
17. The HAT1 inhibiter and the KAT8 inhibiter are included, the kit for DNA damage improvement.
[claim18]
18. The HAT1 inhibiter is contained, it can use with the KAT8 inhibiter and the HAT1 inhibiter with combined use, the DNA damage improvement medicine.
[claim19]
19. The KAT8 inhibiter is contained, it can use with the HAT1 inhibiter and the KAT8 inhibiter with combined use, the DNA damage improvement medicine.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOTTORI UNIVERSITY
  • 発明者(英語)
  • MIURA NORIMASA
国際特許分類(IPC)
指定国 (WO201773692)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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