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COMPOSITION INDUCING CELL REPROGRAMMING AND PRODUCTION METHOD FOR MULTIFUNCTION CELLS USING SAID COMPOSITION

外国特許コード F170009104
整理番号 (S2016-0183-N0)
掲載日 2017年6月15日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP083874
国際公開番号 WO 2017086329
国際出願日 平成28年11月15日(2016.11.15)
国際公開日 平成29年5月26日(2017.5.26)
優先権データ
  • 特願2015-223656 (2015.11.16) JP
発明の名称 (英語) COMPOSITION INDUCING CELL REPROGRAMMING AND PRODUCTION METHOD FOR MULTIFUNCTION CELLS USING SAID COMPOSITION
発明の概要(英語) The objective of the present invention is to provide a composition including a substance identified as inducing cell reprogramming. The objective of the present invention is also to provide multifunction cells having high safety when applied to regenerative medicine, using said composition, and a production method therefor. According to the present invention, a cell reprogramming-inducing composition including at least one 30S ribosome protein selected from the group consisting of 30S ribosome protein S2, 30S ribosome protein S8 and 30S ribosome protein S15 as a substance that reprograms cells derived from a mammalian animal is provided. Further, a production method for multifunction cells from somatic cells using said composition is provided.
特許請求の範囲(英語) [claim1]
1. The re-programming induction composition of the cell which at least includes one which is chosen from the group which consists of 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 as the substance which re-programs the cell of mammalian animal origin, 30S ribosomal protein.
[claim2]
2. In the claim 1 which is the 30S ribosomal protein S15 where the aforementioned 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 were isolated and were isolated and were isolated and were refined the 30S ribosomal protein S2 which was refined, the 30S ribosomal protein S8 which was refined, and the composition of statement.
[claim3]
3. In the claim 1 which includes 30S ribosomal protein S2 as the substance which re-programs the cell, or 2 the composition of statement.
[claim4]
4. The cell of the aforementioned mammal origin, either of the claim 1-3 which is the skin cell or the cancer cell of human origin in one the composition of statement.
[claim5]
5. The aforementioned 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 rearrange and either of the claim 1-4 which is the protein in one the composition of the cell of statement.
[claim6]
6. In the somatic cell of mammalian animal origin, the method of inducing re-programming the said cell by at least making one which is chosen from the group which consists of 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 30S ribosomal protein contact.
[claim7]
7. In the claim 6 which is the 30S ribosomal protein S15 where the aforementioned 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 were isolated and were isolated and were isolated and were refined the 30S ribosomal protein S2 which was refined, the 30S ribosomal protein S8 which was refined, and method of statement.
[claim8]
8. In the claim 6 which features that the cell is made to contact with 30S ribosomal protein S2 or 7 method of statement.
[claim9]
9. The aforementioned somatic cell, either of the claim 6-8 which is the cell of human origin in one method of statement.
[claim10]
10. The aforementioned 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 rearrange and either of the claim 6-9 which is the protein in one method of statement.
[claim11]
11. The versatile sex cell which is produced either of the claim 6-10 by one method.
[claim12]
12. The nutrient medium in order to produce the versatile sex cell from somatic cell of the mammalian animal origin which includes one which is chosen from the group which consists of 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 30S ribosomal protein at least, is isolated.
[claim13]
13. In the claim 12 which is the 30S ribosomal protein S15 where the aforementioned 30S ribosomal protein S2, 30S ribosomal protein S8, and 30S ribosomal protein S15 were isolated and were isolated and were isolated and were refined the 30S ribosomal protein S2 which was refined, the 30S ribosomal protein S8 which was refined, and the nutrient medium of statement.
[claim14]
14. 30S ribosomal protein S2 is included, in claim 12 or 13 the nutrient medium of statement.
[claim15]
15. The aforementioned 30S ribosomal protein rearranges and either of the claim 12-14 which is the protein in one the nutrient medium of statement.
[claim16]
16. Either of the claim 1-5 in one the composition of statement, and the nutrient medium kit which consists of the nutrient medium for animal cell culture.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • OHTA KUNIMASA
  • ITO NAOFUMI
国際特許分類(IPC)
指定国 (WO201786329)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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