TOP > 外国特許検索 > FUSION PROTEIN OR CONJUGATED PROTEIN, INTRACELLULAR DELIVERY CARRIER, PARTIAL PEPTIDE, CELL MEMBRANE PERMEATION ENHANCER, DNA, AND VECTOR

FUSION PROTEIN OR CONJUGATED PROTEIN, INTRACELLULAR DELIVERY CARRIER, PARTIAL PEPTIDE, CELL MEMBRANE PERMEATION ENHANCER, DNA, AND VECTOR NEW

外国特許コード F170009131
整理番号 S2017-0182-N0
掲載日 2017年7月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP066455
国際公開番号 WO 2016199674
国際出願日 平成28年6月2日(2016.6.2)
国際公開日 平成28年12月15日(2016.12.15)
優先権データ
  • 特願2015-118432 (2015.6.11) JP
発明の名称 (英語) FUSION PROTEIN OR CONJUGATED PROTEIN, INTRACELLULAR DELIVERY CARRIER, PARTIAL PEPTIDE, CELL MEMBRANE PERMEATION ENHANCER, DNA, AND VECTOR NEW
発明の概要(英語) The present invention addresses the problem of providing: a fusion protein or conjugated protein having excellent cell membrane permeability, containing a partial peptide derived from human, and suitable for intracellular delivery; an intracellular delivery carrier comprising such a fusion protein or conjugated protein; a partial peptide; a cell membrane permeation enhancer comprising the partial peptide; DNA; and a vector. The fusion protein or conjugated protein has a partial peptide comprising at least seven successive amino acid residues of an amino acid sequence encoded by a predetermined DNA, and a ligand directly or indirectly bound to the partial peptide and having the capability of binding to cell surfaces. The ligand is preferably an antibody. The intracellular delivery carrier comprises the fusion protein or conjugated protein. The cell membrane permeation enhancer comprises the partial peptide.
特許請求の範囲(英語) [claim1]
1. (A) from (d) in either below DNA of statement the cord/code among the amino acid arrangements which are done the part peptide which consists of the amino acid residue which 7 continue at least and,
The ligand which the said part peptide direct or is connected indirectly, at the same time, possesses the connection talent for the cell surface and,
It possesses, the fusion protein or the conjugated protein.
(A) In arrangement number 1, 2 or 3 DNA which possesses the base arrangement which amino acid arrangement of statement the cord/code is done
(B) In arrangement number 1, 2 or 3 in the base arrangement which amino acid arrangement of statement the cord/code is done complimentary base arrangement and [sutorinjiento] DNA which possesses the base arrangement which [haiburidaizu] it is possible under condition
(C) DNA which possesses the base arrangement which the amino acid arrangement which 1 or plural amino acids substitutes in arrangement number 1, 2 or 3 at the time of amino acid arranging of statement, deficiency and/or is added the cord/code is done
(D) In arrangement number 1, 2 or 3 DNA which consists of the base arrangement which amino acid arrangement of statement and the amino acid arrangement which possesses homology of 90% or more the cord/code is done
[claim2]
2. The aforementioned ligand, is the antibody, in claim 1 the fusion protein or the conjugated protein of statement.
[claim3]
3. In claim 1 or 2 fusion protein of statement.
[claim4]
4. It consists of the fusion protein or the conjugated protein of statement in claim 1 or 2, the carrier for delivery inside cell.
[claim5]
5. (A) from (d) in either below DNA of statement the cord/code among the amino acid arrangements which are done the part peptide which consists of the amino acid residue which 7 continue at least.
(A) In arrangement number 1, 2 or 3 DNA which possesses the base arrangement which amino acid arrangement of statement the cord/code is done
(B) In arrangement number 1, 2 or 3 in the base arrangement which amino acid arrangement of statement the cord/code is done complimentary base arrangement and [sutorinjiento] DNA which possesses the base arrangement which [haiburidaizu] it is possible under condition
(C) DNA which possesses the base arrangement which the amino acid arrangement which 1 or plural amino acids substitutes in arrangement number 1, 2 or 3 at the time of amino acid arranging of statement, deficiency and/or is added the cord/code is done
(D) In arrangement number 1, 2 or 3 DNA which consists of the base arrangement which amino acid arrangement of statement and the amino acid arrangement which possesses homology of 90% or more the cord/code is done
[claim6]
6. The cell membrane transmitted accelerator which consists of the part peptide of statement in claim 5.
[claim7]
7. In claim 1 or 2 in the fusion protein or claim 5 of statement DNA which the part peptide of statement the cord/code is done.
[claim8]
8. The vector where DNA of statement is installed in claim 7.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KEIO UNIVERSITY
  • 発明者(英語)
  • SUDO KEI
  • NIIKURA KEISUKE
  • DOI NOBUHIDE
国際特許分類(IPC)
指定国 (WO2016199674)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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