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NUCLEIC ACID DELIVERY CARRIER, NUCLEIC ACID DELIVERY KIT, AND NUCLEIC ACID DELIVERY METHOD NEW

外国特許コード F170009132
整理番号 S2017-0179-N0
掲載日 2017年7月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP067382
国際公開番号 WO 2016199895
国際出願日 平成28年6月10日(2016.6.10)
国際公開日 平成28年12月15日(2016.12.15)
優先権データ
  • 特願2015-117429 (2015.6.10) JP
発明の名称 (英語) NUCLEIC ACID DELIVERY CARRIER, NUCLEIC ACID DELIVERY KIT, AND NUCLEIC ACID DELIVERY METHOD NEW
発明の概要(英語) The purpose of the present invention is to provide a nucleic acid delivery carrier, a nucleic acid delivery kit, and a nucleic acid delivery method which have an excellent effect of inhibiting cell death after nucleic acid delivery and have excellent efficiency of delivering nucleic acids into cells. This carrier for delivery of nucleic acids into cells comprises a ribosome having a membrane fusion capability, wherein the ribosome includes a cationic lipid as a membrane constituent, and the surface of the ribosome is modified with a temperature-responsive polymer. This nucleic acid delivery carrier is optimally used to deliver nucleic acids into cervical cancer cells. This kit for delivering nucleic acids into cells includes the aforementioned delivery carrier. The nucleic acid delivery method for delivering nucleic acids into cells involves a step for contacting isolated cells with a complex of the aforementioned nucleic acid delivery carrier and nucleic acids, or, a step for dosing a non-human animal with a complex of the aforementioned nucleic acid delivery carrier and nucleic acids.
特許請求の範囲(英語) [claim1]
1. It consists of the liposome which possesses membrane fusion efficiency, being the carrier for nuclear acid delivery to inside cell,
As for the aforementioned liposome, as a membrane constitution component implication the cation characteristic lipid,
The surface of the aforementioned liposome was decorated with the temperature responsiveness polymer, the carrier for nuclear acid delivery.
[claim2]
2. The lower limit critical solution temperature for the water of the aforementioned temperature responsiveness polymer is the 35.0-45.0.deg.C, in claim 1 the carrier for nuclear acid delivery of statement.
[claim3]
3. The aforementioned liposome includes the phosphatide as a membrane constitution component, in claim 1 or 2 the carrier for nuclear acid delivery of statement.
[claim4]
4. It is used for the delivery of the nuclear acid to inside the uterus neck cancer cell, from claim 1 in either of 3 the carrier for nuclear acid delivery of statement.
[claim5]
5. From claim 1 the carrier for nuclear acid delivery of statement is included in either of 4, the kit for nuclear acid delivery to inside cell.
[claim6]
6. The process which from claim 1 makes with the mixture of the carrier and nuclear acid for nuclear acid delivery of statement and the cell contact which is isolated in either of 4, or,
The mixture of the carrier and nuclear acid for the aforementioned nuclear acid delivery it possesses the process which is prescribed to the animal which excludes the person, nuclear acid delivery method to inside the cell.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KEIO UNIVERSITY
  • 発明者(英語)
  • KANAZAWA HIDEKO
  • WANG JIAN
国際特許分類(IPC)
指定国 (WO2016199895)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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