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COMPOSITION FOR PREVENTING OR AMELIORATING LOSS OF HAIR AND GRAYING OF HAIR, AND USE THEREOF NEW

外国特許コード F170009143
整理番号 (S2016-0313-N0)
掲載日 2017年8月8日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP000610
国際公開番号 WO 2017122668
国際出願日 平成29年1月11日(2017.1.11)
国際公開日 平成29年7月20日(2017.7.20)
優先権データ
  • 特願2016-003424 (2016.1.12) JP
発明の名称 (英語) COMPOSITION FOR PREVENTING OR AMELIORATING LOSS OF HAIR AND GRAYING OF HAIR, AND USE THEREOF NEW
発明の概要(英語) The present invention provides a composition for preventing or ameliorating newly occurring loss of hair and a composition for preventing or ameliorating graying of hair. More specifically, the present invention provides a composition containing, as an active ingredient, an agent for stabilizing the expression of collagen XVII, preferably a collagen XVII decomposition inhibitor such as an ELANE inhibitor, or an agent for promoting the repairing of DNA or an agent for inhibiting the damage of DNA. When a composition containing, as an active ingredient, a collagen XVII decomposition inhibitor, such as an ELANE inhibitor, is administered to a mammal, an advantageous effect for preventing the loss of hair and the graying of hair can be produced. As the ELANE inhibitor, the collagen XVII decomposition inhibitor or the agent for promoting the repairing of DNA, a low-molecular-weight compound, a polypeptide, a protein, an antibody, or a nucleic acid drug such as an antisense oligonucleotide and siRNA can be used. Also provided is a method for screening for a substance that is effective for the prevention of the loss of hair and the graying of hair.
特許請求の範囲(英語) [claim1]
1. Being the composition in order to use for the control or improvement of dehairing, XVII type collagen revelation the medicine which is stabilized, it features that the disassembly inhibiter of XVII type collagen is contained desirably, the composition.
[claim2]
2. Being the composition in order to use for the control or improvement of white hair conversion, XVII type collagen revelation the medicine which is stabilized, it features that the disassembly inhibiter of XVII type collagen is contained desirably, the composition.
[claim3]
3. Being the composition in order to use for the control of miniature conversion of the hair package, XVII type collagen revelation the medicine which is stabilized, it features that the disassembly inhibiter of XVII type collagen is contained desirably, the composition.
[claim4]
4. Being the composition in order to use for the remedy or prevention of the alopecia, XVII type collagen revelation the medicine which is stabilized, it features that the disassembly inhibiter of XVII type collagen is contained desirably, the composition.
[claim5]
5. The alopecia, the alopecia where the hair gradually keeps becoming thin, especially, features that it is each alopecia which is selected from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia, the composition of claim 4 statement.
[claim6]
6. Being the composition in order to use for the control or improvement of dehairing, the sphere erasutaze inhibiter, the MMP inhibiter, the NADPH oxydase inhibiter and the ADAM inhibiter of the good inside, and/or it features that the antioxidant is contained, the composition.
[claim7]
7. Being the composition in order to use for the control or improvement of white hair conversion, the sphere erasutaze inhibiter, the MMP inhibiter, the NADPH oxydase inhibiter and the ADAM inhibiter of the good inside, and/or it features that the antioxidant is contained, the composition.
[claim8]
8. Being the composition in order to use for the control of miniature conversion of the hair package, the sphere erasutaze inhibiter, the MMP inhibiter, the NADPH oxydase inhibiter and the ADAM inhibiter of the good inside, and/or it features that the antioxidant is contained, the composition.
[claim9]
9. Being the composition in order to use for the remedy or prevention of the alopecia, the sphere erasutaze inhibiter, the MMP inhibiter, the NADPH oxydase inhibiter and the ADAM inhibiter of the good inside, and/or it features that the antioxidant is contained, the composition.
[claim10]
10. The alopecia, features that it is each alopecia which is selected from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia, the composition of claim 9 statement.
[claim11]
11. The sphere erasutaze inhibiter of the good inside, the .alpha.1 anti trypsin (.alpha.1-AT), the shiberesutatsutonatoriumu hydrate, is the chemical compound which is selected from the group which consists of ONO-6818 and deperesutatsuto, either of the claim 6-10 the composition of one section statement.
[claim12]
12. The sphere erasutaze inhibiter of the good inside, the monoclonal antibody or the fragment, is anchisensuorigonukureochido or siRNA, either of the claim 6-10 the composition of one section statement.
[claim13]
13. The MMP inhibiter, is the chemical compound which is selected from the group which consists of Marimastat, Batimastat, PD166793, Ro32-3555, WAY170523, TIMP1, TIMP2, TIMP3, TIMP4 and UK370106, either of the claim 6-10 the composition of one section statement.
[claim14]
14. The NADPH oxydase inhibiter, is the chemical compound which is selected from the group which consists of aposhinin, AEBSF, GK-136901, ML171, VAS2870, and VAS3947, either of the claim 6-10 the composition of one section statement.
[claim15]
15. The antioxidant, asukorubin acid, is the chemical compound which is selected from the group which consists of edarabon, .alpha.-tokohueroru, glutathione, katekin, and less veratrole, either of the claim 6-10 the composition of one section statement.
[claim16]
16. It is the medicine composition, either of the claim 1-15 the composition of one section statement.
[claim17]
17. It is the composition for beauty care, either of the claim 1-15 the composition of one section statement.
[claim18]
18. It is the beauty care supplement, either of the claim 1-15 the composition of one section statement.
[claim19]
19. It is the oral medicine, the injection medicine or the medicine for the crust, either of the claim 1-15 the composition of one section statement.
[claim20]
20. Control or improvement of control or improvement and white hair conversion of dehairing, and/or being method in order the screening to do the substance which is effective to the control of miniature conversion of the hair package,
i) With in vitro sphere erasutaze of the good inside (ELANE) with the process which makes with the test substance contact,
II) The process which measures the activity of sphere erasutaze of the good inside, and
III) The process which is decided whether or not the said test substance sphere erasutaze of the good inside (ELANE) decreases activity,
It includes, method.
[claim21]
21. The alopecia where the hair gradually keeps becoming thin, especially, being the medicine composition in order to use for the remedy or prevention of each alopecia which is selected from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia, XVII type collagen protein or that the cord/code the nuclear acid which is done, or XVII type collagen it features that the medicine which is stabilized or the medicine which is made to reveal stably are contained, the medicine composition.
[claim22]
22. The alopecia where the hair gradually keeps becoming thin, especially, being the medicine composition in order to use for the remedy or prevention of each alopecia which is selected from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia, revelation of XVII type collagen it features that chemical compound or the nuclear acid which increase the cell which reveals chemical compound or nuclear acid or the (ii) XVII type collagen which it rises or is stabilized, or are contained in the (i) hair package trunk cell or the angular conversion cell, the medicine composition.
[claim23]
23. The alopecia where the hair gradually keeps becoming thin, especially, from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia remedy or prevention of each alopecia which is selected, and/or being screening method of useful chemical compound in control of white hair conversion,
i) The process which makes chemical compound the hair package trunk cell or the angular conversion cell contact with in vitro,
II) The process which inspects the change of the revelation quantity of XVII type collagen in the hair package trunk cell or the angular conversion cell, and
III) The revelation quantity of XVII type collagen in the hair package trunk cell or the angular conversion cell the process which identifies the chemical compound which it increases or is stabilized and,
It includes, screening method.
[claim24]
24. Being the composition in order to use for the control, improvement or prevention of dehairing, it features that it contains the medicine which promotes DNA damage restoration or the medicine which controls the DNA damage, the composition.
[claim25]
25. Being the composition in order to use for the control, improvement or prevention of white hair conversion, it features that it contains the medicine which promotes DNA damage restoration or the medicine which controls the DNA damage, the composition.
[claim26]
26. Being the composition in order to use for the prevention of miniature conversion of the hair package, it features that it contains the medicine which promotes DNA damage restoration or the medicine which controls the DNA damage, the composition.
[claim27]
27. Being the composition in order to use for the remedy or prevention of the alopecia, the composition which features that it contains the medicine which promotes DNA damage restoration or the medicine which controls the DNA damage.
[claim28]
28. The alopecia, the alopecia where the hair gradually keeps becoming thin, especially, features that it is each alopecia which is selected from the group which consists of the senile alopecia, the man type alopecia, the pervasion characteristic alopecia, the woman type alopecia, the medicine alopecia, and the scar characteristic alopecia, the composition of claim 27 statement.
[claim29]
29. Promotes DNA damage restoration the medicine or controls the DNA damage the medicine which, the cedar paste (Gigartina tenella) extract and sarukandoragurabura (Sarcandra glabra) extract and sarakadeibesu (Saraca dives) extract and kudoraniapubesensu (Cudrania pubescens) extract and takisodeiumudeisuteichiyumu (Taxodium distichum) extract and rubijiaokutobarisu (Ludwigia octovalis) extract and doichiyantasutonkinenshisu (Deutzianthus tonkinensis) extract and arukoruneatorebioidesu (Alchornea trewioides) extract and berukemiaporihuira (Berchemia polyphylla) extract and gurochideionpuberumu (Glochidion puberum) extract and sasahurasutsumu (Sassafras tzumu) the extract, the cinchona extract, the comfrey extract, the kohinoki extract, the katsukon extract, the burdock extract, the ouren extract, the kurara extract, the chlorella extract and the lavender extractThe kind which is selected from the group which consists of the mematsuyoigusa extract, the rose extract, the amachiyazuru extract, the enmeisou extract, the odorikosou extract, the karotsuto extract, the shinanoki extract, the jiyu extract, the lotus extract, the brown extract, and the okra extract or it features that it is the extract of two kinds or more, either of the claim 24-28 the composition of one section statement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO MEDICAL AND DENTAL UNIVERSITY
  • 発明者(英語)
  • NISHIMURA EMI
  • MATSUMURA HIROYUKI
国際特許分類(IPC)
指定国 (WO2017122668)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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