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MICROARRAY, METHOD FOR MANUFACTURING MICROARRAY, INSPECTION METHOD, AND INSPECTION KIT UPDATE

外国特許コード F170009144
整理番号 (S2016-0331-N0)
掲載日 2017年8月8日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP001724
国際公開番号 WO 2017130829
国際出願日 平成29年1月19日(2017.1.19)
国際公開日 平成29年8月3日(2017.8.3)
優先権データ
  • 特願2016-011762 (2016.1.25) JP
発明の名称 (英語) MICROARRAY, METHOD FOR MANUFACTURING MICROARRAY, INSPECTION METHOD, AND INSPECTION KIT UPDATE
発明の概要(英語) The present invention provides a microarray with which it is possible to simultaneously react a blood sample and a plurality of types of reagent red blood cells in the same reaction phase, and that enables detection and identification of irregular antibodies in a simple manner and at a high sensitivity. This microarray for detecting and identifying irregular antibodies in a blood sample is characterized in that sets of red blood cells or red blood cell ghosts presenting a known antigen on the cell surface are immobilized in a regular arrangement on a substrate. This inspection method for inspecting irregular antibodies in a blood sample is provided with: a step for bringing a blood sample collected from a subject into contact with the microarray and performing a first antigen-antibody interaction; a step for cleaning the microarray, bringing a labeled anti-human antibody into contact therewith, and performing a second antigen-antibody interaction; and a step for detecting the labeled anti-human antibody.
特許請求の範囲(英語) [claim1]
1. Being micro array in order it detects and to identify the irregular antibody in the blood sample and,
The micro array which features that set of the red corpuscle or red corpuscle ghost which on the baseplate presents the known antigen on the cell surface is fixed systematically.
[claim2]
2. The aforementioned known antigen, D, C, E, c, e, f and C (w), V, K, k and Kp (a), Kp (b), Js (a), Js (b), Fy (a), Fy (b), Jk (a), Jk (b), Xg (a), Le (a), Le (b), S and s, M, N and P [1], Lu (a), Lu (b), Di (a), Di (b) from the group which consists ofAt least it is one which is chosen, in claim 1 micro array of statement.
[claim3]
3. Being production method of micro array in order it detects and to identify the irregular antibody in the blood sample and,
Production method of the micro array which features that the process which it drips to the position where it can decide the set of the solution which includes the red corpuscle or red corpuscle ghost on the baseplate presenting the known antigen on the cell surface, beforehand individually, dries is had.
[claim4]
4. Being method in order to inspect the irregular antibody in the blood sample,
The process which makes the blood sample which was picked from the subject micro array of statement contact, in claim, 1 or 2 does the 1st antigen antibody reaction and,
The process where you wash the aforementioned micro array, makes the anti- human antibody contact which the sign is done, does the 2nd antigen antibody reaction and,
The aforementioned sign the process which detects the anti- human antibody which is done and,
The inspection method of featuring that it has.
[claim5]
5. The aforementioned blood sample, the blood, is the serum, or the blood plasma, in claim 4 inspection method of statement.
[claim6]
6. Being the kit in order to inspect the irregular antibody in the blood sample,
In claim 1 or 2 micro array of statement and,
The sign the anti- human antibody which is done and,
The inspection kit which features that it has.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KITASATO INSTITUTE
  • 発明者(英語)
  • HACHIMURA KAZUO
  • NAGASHIO RYO
  • SATO YUICHI
  • OTANI SHINICHI
  • KANOH YUHSAKU
国際特許分類(IPC)
指定国 (WO2017130829)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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