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Nucleic acid-containing polymeric micelle complex and method of manufacturing the same

Foreign code F170009168
File No. K10503TW
Posted date Sep 12, 2017
Country Taiwan
Application number 103126841
Gazette No. 201536351
Gazette No. I565479
Date of filing Aug 6, 2014
Gazette Date Oct 1, 2015
Gazette Date Jan 11, 2017
Priority data
  • P2013-163106 (Aug 6, 2013) JP
Title Nucleic acid-containing polymeric micelle complex and method of manufacturing the same
Abstract (TWI565479)
A nucleic acid-containing polymeric micelle complex of the present invention comprises an uncharged hydrophilic polymer chain block and a block copolymer containing cationic polymer chain block; and two single-strand DNAs having 1000 bases or more and containing complementary base sequences each other, a double-strand DNA having 1000 base pairs or more, wherein at least a part of the double helix is dissociated and forms a single chain structure, or a single-strand DNA having 1000 bases or more.
Scope of claims [claim1]
1. Kinds of intension nucleic acid's high polymer micelle complexes, its characteristic for by including the non-electric charge water affinity high polymer chain block and positive ion high polymer chain block's block copolymer, and is contained above 2nd single laid DNA 1000 basic group length each other supplementary basic group sequence, at least one of part of dissociation double helix structures to become the single laid structure 1000 basic groups above double strand DNA to the length, or above 1 of single laid DNA 1000 basic group lengths forms.
[claim2]
2. Like the request item of 1 intension nucleic acid's high polymer micelle complex, it is by including the non-electric charge water affinity high polymer chain block and positive ion high polymer chain block block copolymer, and contains 2 single laid DNA that above 1000 basic group lengths each other supplementary basic group sequence becomes, or at least one of part of dissociation double helix structures becomes the single laid structure 1000 basic groups above double strand DNA to the length to form.
[claim3]
3. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, above single laid DNA is above 2000 basic group lengths, above double strand DNA is 2000 basic groups to the length above.
[claim4]
4. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, in the river character media the use dynamic light scattering method's average grain diameters are below 100nm.
[claim5]
5. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, DNA and because of static electricity interaction but with the DNA union's positive ion high polymer chain block forms the core part, the non-electric charge water affinity high polymer chain block forms the shell part.
[claim6]
6. Like request item of 5 intension nucleic acid high polymer micelle complexes, the above core part the average grain diameters are below 50nm.
[claim7]
7. Like request item 1 or 2 intension nucleic acid's high polymer micelle complex, it is the spheroid shape.
[claim8]
8. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, above single laid DNA or above double strand DNA are the striations.
[claim9]
9. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, at least of a sub-system above block copolymers each other crosses linking.
[claim10]
10. Like request item 1 or 2 intension nucleic acid high polymer micelle complex, in the principal chain or side chain above positive ion high polymer chain block, covalent bond knot hydrophobic base.
[claim11]
11. Like request item 1 either 2 intension nucleic acid's high polymer micelle complex, it has the ethyl group amine structure or the propyl amine structure in the side chain of above positive ion high polymer chain block.
[claim12]
12. 1 intension nucleic acid the manufacture of method of high polymer micelle complex, it is the manufacture accepts DNA intension nucleic acid the method of high polymer micelle complex, its characteristic to have the following step: Will include the non-electric charge water affinity high polymer chain block and positive ion high polymer chain block block copolymer, and causes 1000 basic groups' at least one of part of dissociation double helix structures condition double strand DNA to above, performs to mix in the river character media.
[claim13]
13. Like request item of 12 intension nucleic acid the manufacture of method of high polymer micelle complex, above double strand DNA is 2000 basic groups to the length above.
[claim14]
14. Like request item 12 or 13 intension nucleic acid the manufacture of method of high polymer micelle complex, above double strand DNA is the striation.
[claim15]
15. Like request item 12 or 13 intension nucleic acid the manufacture of method of high polymer micelle complex, above double strand DNA is causes his transsexual over 60℃.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • KATAOKA KAZUNORI
  • OSADA KENSUKE
  • TOCKARY THEOFILUS AGRIOS
IPC(International Patent Classification)
Reference ( R and D project ) PRESTO Molecular technology and creation of new functions AREA
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