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Nucleic acid-encapsulating polymer micelle complex and method for producing same NEW

外国特許コード F170009170
整理番号 K10503WO
掲載日 2017年9月12日
出願国 大韓民国
出願番号 20167001466
公報番号 20160021291
公報番号 101770705
出願日 平成26年8月5日(2014.8.5)
公報発行日 平成28年2月24日(2016.2.24)
公報発行日 平成29年8月23日(2017.8.23)
国際出願番号 JP2014070567
国際公開番号 WO2015020026
国際出願日 平成26年8月5日(2014.8.5)
国際公開日 平成27年2月12日(2015.2.12)
優先権データ
  • 特願2013-163106 (2013.8.6) JP
  • 2014WO-JP70567 (2014.8.5) WO
発明の名称 (英語) Nucleic acid-encapsulating polymer micelle complex and method for producing same NEW
発明の概要(英語) (KR101770705)
A nucleic acid-encapsulating polymer micelle complex is formed of a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polymer chain block; and two single-stranded DNA molecules having mutually complementary base sequences of 1000 or more bases in length, double-stranded DNA of 1000 or more base pairs in length in which at least a part of a double helix structure is dissociated and forms a single-stranded structure, or one single-stranded DNA molecule of 1000 or more bases in length.
(From EP3031447 A1)
特許請求の範囲(英語) [claim1]
1. As for under including block copolymers and 1000 salty tastes 2 forever above each other become accomplished with the base sequence which is tablecloth 1 sway DNA and double the part of the helix structure is dissociated the charge-mass ratio hydrophilic high-molecular sway block and the positive ion high-molecular sway block, 1000 base pair which become 1 sway structure forever 1 with 1 sway DNA of above, forever 2 sway DNA or 1000 salty tastes of above is formed is become accomplished and, is a specific form the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim2]
2. There is in a 1st claim,
As for under including block copolymers and 1000 salty tastes 2 forever above each other become accomplished with the base sequence which is tablecloth 1 sway DNA or double the part of the helix structure is dissociated the charge-mass ratio hydrophilic high-molecular sway block and the positive ion high-molecular sway block, 1000 base pair which are becoming with 1 sway structure forever with 2 sway DNA of above, is formed is become accomplished the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim3]
3. The 1st claim or there is in a 2nd claim,
As for minute description 1 sway DNA 2000 salty tastes to be an above forever, and as for minute description 2 sway DNA 2000 base pair forever is an above the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim4]
4. The 1st claim or there is in a 2nd claim,
The average particle diameter by the dynamic storehouse scattering method in hydrogenous medium is below 100 the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim5]
5. The 1st claim or there is in a 2nd claim,
By DNA and a power failure interaction with DNA the positive ion high-molecular sway block which combined forms a core part, and the charge-mass ratio hydrophilic high-molecular sway block is forming a shell part the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim6]
6. There is in a 5th claim,
Average particle diameter of minute description core part is below 50 the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim7]
8. The 1st claim or there is in a 2nd claim,
As for minute description 1 sway DNA or minute description 2 sway DNA is a line the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim8]
9. The 1st claim or there is in a 2nd claim,
As for part of minute description block copolymer each other is building a bridge the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim9]
10. The 1st claim or there is in a 2nd claim,
To week sway or the branched chain of the minute description positive ion high-molecular sway block hydrophoby giga is covalent bond the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim10]
11. The 1st claim or there is in a 2nd claim,
Has an ethyl amine structure or a profile amine structure to the branched chain of the minute description positive ion high-molecular sway block the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim11]
12. The nuclear acid containment high-molecular micelle complex which accommodated DNA as for under manufacturing as method,
The charge-mass ratio hydrophilic high-molecular sway block and the positive ion high-molecular sway block as for under including block copolymer and double part of the helix structure at the time of Harry 2 sway DNA of above 1000 base pair of Keane situation the low of mixing includes a process from in hydrogenous medium,
As for the minute description nuclear acid containment high-molecular micelle complex is a specific form manufacturing method of the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim12]
13. There is in a 12th claim,
As for minute description 2 sway DNA 2000 base pair forever is an above manufacturing method of the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim13]
14. The 12th claim or there is in a 13th claim,
As for minute description 2 sway DNA is a line manufacturing method of the nuclear acid containment high-molecular micelle complex the fact that with feature.
[claim14]
15. The 12th claim or there is in a 13th claim,
As for minute description 2 sway DNA metamorphose from more than 60.deg.C manufacturing method of the nuclear acid containment high-molecular micelle complex the fact that with feature.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KATAOKA KAZUNORI
  • OSADA KENSUKE
  • TOCKARY THEOFILUS AGRIOS
国際特許分類(IPC)
参考情報 (研究プロジェクト等) PRESTO Molecular technology and creation of new functions AREA
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