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Substance-encapsulating vesicle and process for producing the same NEW

外国特許コード F170009179
整理番号 AF12-07WO
掲載日 2017年9月12日
出願国 アメリカ合衆国
出願番号 201113699238
公報番号 20130202711
公報番号 9750687
出願日 平成23年5月23日(2011.5.23)
公報発行日 平成25年8月8日(2013.8.8)
公報発行日 平成29年9月5日(2017.9.5)
国際出願番号 JP2011061790
国際公開番号 WO2011145745
国際出願日 平成23年5月23日(2011.5.23)
国際公開日 平成23年11月24日(2011.11.24)
優先権データ
  • 特願2010-117821 (2010.5.21) JP
  • 特願2010-117823 (2010.5.21) JP
  • 2011WO-JP61790 (2011.5.23) WO
発明の名称 (英語) Substance-encapsulating vesicle and process for producing the same NEW
発明の概要(英語) (US9750687)
Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly.
Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
特許請求の範囲(英語) [claim1]
1. A vesicle comprising: a membrane containing a first polymer, which is a block copolymer having an uncharged hydrophilic segment and a first charged segment, and a second polymer, which has a second charged segment charged oppositely to the first charged segment, said membrane defining a cavity surrounded thereby and having a first charged segment to second charged segment ratio of 0.3 to less than 3.00; and
a charged substance encapsulated in the cavity.
[claim2]
2. A vesicle according to claim 1, wherein the membrane has a trilaminar structure comprising an outer layer, an intermediate layer, and an inner layer.
[claim3]
3. A vesicle according to claim 1, wherein the charged substance is selected from the group consisting of biomolecules, organic compounds and inorganic substances.
[claim4]
4. A vesicle according to claim 1, wherein the first polymer is a block copolymer containing an uncharged hydrophilic segment and an anionic segment, and the second polymer is a block copolymer containing an uncharged hydrophilic segment and a cationic segment and/or a polymer containing a cationic segment but no uncharged hydrophilic segment.
[claim5]
5. A vesicle according to claim 1, wherein the first polymer is a block copolymer containing an uncharged hydrophilic segment and a cationic segment, and the second polymer is a block copolymer containing an uncharged hydrophilic segment and an anionic segment and/or a polymer containing an anionic segment but no uncharged hydrophilic segment.
[claim6]
6. A vesicle according to claim 4 or 5, wherein the anionic segment is nucleic acid.
[claim7]
7. A vesicle according to claim 4 or 5, wherein the cationic segment is polyamine.
[claim8]
8. A vesicle according to claim 4 or 5, wherein the uncharged hydrophilic segment is polyalkylene glycol.
  • 発明者/出願人(英語)
  • KATAOKA KAZUNORI
  • KISHIMURA AKIHIRO
  • ANRAKU YASUTAKA
  • MIYATA KANJIRO
  • CHUANOI SAYAN
  • SUMA TOMOYA
  • OBA MAKOTO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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