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Substance-encapsulating vesicle and process for producing the same

Foreign code F170009179
File No. AF12-07WO
Posted date Sep 12, 2017
Country United States of America
Application number 201113699238
Gazette No. 20130202711
Gazette No. 9750687
Date of filing May 23, 2011
Gazette Date Aug 8, 2013
Gazette Date Sep 5, 2017
International application number JP2011061790
International publication number WO2011145745
Date of international filing May 23, 2011
Date of international publication Nov 24, 2011
Priority data
  • P2010-117821 (May 21, 2010) JP
  • P2010-117823 (May 21, 2010) JP
  • 2011WO-JP61790 (May 23, 2011) WO
Title Substance-encapsulating vesicle and process for producing the same
Abstract (US9750687)
Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly.
Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
Scope of claims [claim1]
1. A vesicle comprising: a membrane containing a first polymer, which is a block copolymer having an uncharged hydrophilic segment and a first charged segment, and a second polymer, which has a second charged segment charged oppositely to the first charged segment, said membrane defining a cavity surrounded thereby and having a first charged segment to second charged segment ratio of 0.3 to less than 3.00; and
a charged substance encapsulated in the cavity.
[claim2]
2. A vesicle according to claim 1, wherein the membrane has a trilaminar structure comprising an outer layer, an intermediate layer, and an inner layer.
[claim3]
3. A vesicle according to claim 1, wherein the charged substance is selected from the group consisting of biomolecules, organic compounds and inorganic substances.
[claim4]
4. A vesicle according to claim 1, wherein the first polymer is a block copolymer containing an uncharged hydrophilic segment and an anionic segment, and the second polymer is a block copolymer containing an uncharged hydrophilic segment and a cationic segment and/or a polymer containing a cationic segment but no uncharged hydrophilic segment.
[claim5]
5. A vesicle according to claim 1, wherein the first polymer is a block copolymer containing an uncharged hydrophilic segment and a cationic segment, and the second polymer is a block copolymer containing an uncharged hydrophilic segment and an anionic segment and/or a polymer containing an anionic segment but no uncharged hydrophilic segment.
[claim6]
6. A vesicle according to claim 4 or 5, wherein the anionic segment is nucleic acid.
[claim7]
7. A vesicle according to claim 4 or 5, wherein the cationic segment is polyamine.
[claim8]
8. A vesicle according to claim 4 or 5, wherein the uncharged hydrophilic segment is polyalkylene glycol.
  • Inventor, and Inventor/Applicant
  • KATAOKA KAZUNORI
  • KISHIMURA AKIHIRO
  • ANRAKU YASUTAKA
  • MIYATA KANJIRO
  • CHUANOI SAYAN
  • SUMA TOMOYA
  • OBA MAKOTO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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