TOP > 外国特許検索 > Method for screening of therapeutic agent for hyperlipemia

Method for screening of therapeutic agent for hyperlipemia NEW

外国特許コード F170009183
整理番号 A261-11WO
掲載日 2017年9月12日
出願国 アメリカ合衆国
出願番号 201013511028
公報番号 20120244539
公報番号 9090932
出願日 平成22年11月25日(2010.11.25)
公報発行日 平成24年9月27日(2012.9.27)
公報発行日 平成27年7月28日(2015.7.28)
国際出願番号 JP2010070959
国際公開番号 WO2011065389
国際出願日 平成22年11月25日(2010.11.25)
国際公開日 平成23年6月3日(2011.6.3)
優先権データ
  • 特願2009-269593 (2009.11.27) JP
  • 2010WO-JP70959 (2010.11.25) WO
発明の名称 (英語) Method for screening of therapeutic agent for hyperlipemia NEW
発明の概要(英語) (US9090932)
Disclosed are a highly safe treatment method for hyperlipidemia and a therapeutic agent for hyperlipidemia.
Specifically, the invention provides a novel method for screening an agent for treating hyperlipidemia, more specifically, a method for screening a substance that can inhibit the production or function of gangliosides, particularly GM3, or inhibit the activity or expression of GM3 synthase to reduce a blood lipid level.
A pharmaceutical composition, which can specifically inhibit the production of gangliosides, particularly GM3, thereby effective for hyperlipidemia treatment, and others are also provided.
特許請求の範囲(英語) [claim1]
1. A method for screening a GM3 synthase specific inhibitor having a blood lipid level lowering activity that specifically inhibits GM3 synthase expression, which comprises: contacting a test substance with a cell selected from the group consisting of an adipocyte and a hepatocyte, wherein the cell expresses GM3 synthase;
selecting a test substance that specifically decreases the expression level of GM3 synthase as compared to a control;
administering the selected test substance to a non-human apoE-deficient animal; and
determining a Chylomicron (CM) level, a Very Low Density Lipoprotein (VLDL) level or a Low Density Lipoprotein (LDL) level in blood in the non-human apoE-deficient animal and selecting a test substance having a blood lipid level lowering activity that specifically inhibits GM3 synthase expression and reduces the CM, VLDL or LCL level in blood by 10% or more as compared to a control.
[claim2]
2. The screening method according to claim 1, which further comprises selecting a test substance that reduces a blood cholesterol level and/or a blood triglyceride level.
[claim3]
3. The method according to claim 1, wherein the non-human animal has a higher blood lipid level than normal level.
[claim4]
4. The method according to claim 1, wherein the non-human animal is a mouse.
  • 発明者/出願人(英語)
  • INOKUCHI JINICHI
  • NAGAFUKU MASAKAZU
  • HAYAMIZU HIROTAKA
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Clarification of the Biological Functions of Sugar Chains and the Use of this Knowledge in Applied Technologies AREA
ライセンスをご希望の方、特許の内容に興味を持たれた方は、問合せボタンを押してください。

PAGE TOP

close
close
close
close
close
close