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Planar patch clamp device and planar patch clamp system NEW 新技術説明会

外国特許コード F170009195
整理番号 AF19-07TW
掲載日 2017年9月12日
出願国 台湾
出願番号 103129925
公報番号 201536915
出願日 平成26年8月29日(2014.8.29)
公報発行日 平成27年10月1日(2015.10.1)
優先権データ
  • 特願2013-180684 (2013.8.30) JP
発明の名称 (英語) Planar patch clamp device and planar patch clamp system NEW 新技術説明会
発明の概要(英語) (TW201536915)
A planar patch clamp device comprising: an electrically non-conductive substrate (2) having a through-hole (3) which passes liquid yet does not pass cells in a cell arrangement region (4); a first liquid reservoir unit (6) for holding a first electroconductive liquid, the first liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a first surface (2S) of the substrate (2); a first electrode unit (7) arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a second liquid reservoir unit (6') for holding a second electroconductive liquid, the second liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a second surface (2S') of the substrate (2); a second electrode unit (7') arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a liquid feed channel (8) for feeding the second electroconductive liquid to the second liquid reservoir unit (6'); a liquid discharge channel (9) for discharging the second electroconductive liquid from the second liquid reservoir unit (6'); and a valve (10) disposed in the liquid feed channel (8) and/or the liquid discharge channel (9), the valve (10) being capable of permitting or stopping the distribution of the second electroconductive liquid, and permitting or stopping electrical conductivity with the second liquid reservoir unit (6') and the second electrode unit (7').
特許請求の範囲(英語) [claim1]
1. Kinds of plane diaphragms hold back the installment, its has: The electric insulation foundation plate, has first of the surface cell disposition regions and is its second the surface reverse side, and has to pass through the through hole in the cell disposition region, not make cell through, but may cause liquid passing; First stores the fluid department, in first of the superficial side electric insulation foundation plates by may with passing through the way establishment of through hole connection, for maintaining the first conductive liquid; The first electricity pole piece, with first stores the fluid department by to be possible to penetrate the way disposition of first conductive liquid electricity breakover; Second stores the fluid department, in second the superficial side electric insulation foundation plate by may with passing through the way establishment of through hole connection, for maintaining the second conductive liquid; The second electricity pole piece, with second stores the fluid department by to be possible to penetrate the way disposition of second conductive liquid electricity breakover; Delivers the liquid flow road, links in second stores the fluid department, to second stores the fluid department to deliver the fluid second conductive liquid; Arranges the liquid flow road, links in second stores the fluid department, from second stores the fluid department the second conductive liquid row of fluid; With the valve, supposes in delivering the liquid flow road and/or the row of liquid flow road, may allow or stop the circulation of second conductive liquid, and may allow or stop second storing the fluid department and electricity of breakover second electricity pole piece.
[claim2]
2. Like the request item of 1 plane diaphragm holds back the installment, the electric insulation foundation plate has the plural number cell disposition region separately and birthplace of through hole correspondence, and corresponds has plural number second to store the fluid department to the plural number cell disposition page range; Delivers the liquid flow road to deliver the fluid mainstream road and plural number delivers the fluid branch road, this and so on delivered the fluid branch road is the difference delivers the fluid mainstream road, and links separately in plural number second stores the fluid department; Arranges the liquid flow road to have links second stores the plural number of platoon fluid branch road fluid department separately in plural number, flows together to become the platoon fluid mainstream road with the plural number platoon fluid branch road institute; The second electricity pole piece establishes Yu Songye the mainstream road and/or the row of fluid mainstream road; And the valve establishment in delivers the fluid branch road respectively and/or various row of fluid branch roads.
[claim3]
3. Like request item 1 or 2 plane diaphragms hold back the installment, when the valve shuts down, around the valve resistance value is 1 trillion ohm above.
[claim4]
4. 1 kinds of plane diaphragms hold back the system, its has: If requested that the item 1 to the plane of diaphragm threes any institute record holds back the installment; The control department, control above plane diaphragm holds back to install it. The make and breaks of various valves; With the electricity examination department, the examination above plane diaphragm holds back the installment the electrical signals of various electricity pole pieces.
[claim5]
5. Like the request item of 4 plane diaphragms hold back the system, its has the plural number above plane diaphragm to hold back the installment.
[claim6]
6. Like request item 4 or 5 plane diaphragms hold back the system, it has further the light examination department, examines holds back the installment from the above plane diaphragm the cell's of disposition light signal.
[claim7]
7. The methods of 7.1 screening medicament, are use the request item to hold back the installment 1 to threes any item of plane diaphragm, or the request item 4 to the plane of diaphragm seven any institute record hold back the system, screens to the neural network entrusts with the influence the medicament.
  • 出願人(英語)
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • URISU TSUNEO
  • WANG ZHI-HONG
  • UNO HIDETAKA
  • NAGAOKA YASUTAKA
  • KOBAYASHI KEI
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Creation of Nanosystems with Novel Functions through Process Integration AREA
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